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Estimated Out-of-Pocket Costs for Patients With Common Cancers and Private Insurance
Liam Rose1,2, Ganesh Rajasekar3, Anjali Nambiar3
1Stanford University School of Medicine, Palo Alto, California.
JAMA Network Open
|July 21, 2025
Summary
Cancer diagnosis significantly increases out-of-pocket costs (OOPCs) for privately insured patients. Costs escalate with higher cancer stages, highlighting a substantial financial burden.
Area of Science:
- Health Economics
- Oncology
- Health Services Research
Background:
- Cancer diagnosis imposes a significant financial burden on patients, often exacerbated by advanced disease and intensive treatment requirements.
- Understanding the out-of-pocket costs (OOPCs) associated with initial cancer treatment is crucial for assessing patient financial toxicity.
Purpose of the Study:
- To investigate the out-of-pocket costs (OOPCs) associated with the initial treatment of common cancers (breast, colorectal, lung) among privately insured individuals.
- To compare OOPCs across different cancer stages and with individuals without a cancer diagnosis.
Main Methods:
- Retrospective cohort study utilizing administrative claims data from a large US private health insurer linked to SEER cancer registry data.
- Employed difference-in-differences methods to compare OOPCs between cancer patients and a matched control group without cancer.
- Included privately insured individuals aged <65 years in the US (2008-2022) with continuous enrollment.
Main Results:
- An incident cancer diagnosis was associated with a mean monthly OOPC increase of $592.53 in the 6 months post-diagnosis.
- OOPCs demonstrated a monotonic increase with disease stage, ranging from $462.01/month for stage 0 to $719.97/month for stage 4.
- The study included 46,158 patients (19,656 with cancer), with breast, colorectal, and lung cancers being the most common.
Conclusions:
- Privately insured patients incur substantial OOPCs following a cancer diagnosis, with advanced-stage cancer patients facing the highest costs.
- Further research is warranted to explore the clinical and financial implications of these elevated OOPCs for cancer patients.
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