Related Experiment Video
Updated: Sep 14, 2025
08:39
Reduced Complications after Arterial Reconnection in a Rat Model of Orthotopic Liver Transplantation
Published on: November 7, 2020
7.9K
Cognitive dysfunction, psychiatric distress, and functional decline after liver transplantation
Jessica M Ruck1, Emily C Murriel2, Nicole Fortune Hernandez1
1Department of Surgery, Johns Hopkins University School of Medicine, Baltimore, Maryland, USA.
Summary
Long-term cognitive function in liver transplant recipients is often impaired, affecting quality of life. This study found 25% of recipients had below-expectation cognition, linked to higher rates of anxiety and depression.
Area of Science:
- Nephrology
- Transplantation
- Neuroscience
Background:
- Cognitive impairment post-liver transplant is poorly understood long-term.
- It significantly impacts recipients' quality of life.
Purpose of the Study:
- To assess long-term cognitive performance in liver transplant recipients.
- To evaluate the association between cognitive function and mental health outcomes.
Main Methods:
- Single-center cohort study of 120 liver recipients transplanted between 2010-2022.
- Telephone-based cognitive battery assessment >1 year post-transplant.
- Descriptive statistics used to compare depression, anxiety, and self-reported function by cognitive performance.
Main Results:
- 25% of recipients exhibited below-expectation cognition, primarily in verbal learning and memory.
- 46% reported symptoms of depression and/or anxiety.
- Anxiety was significantly less common in those with above-expectation cognition (0%) compared to others (34-38%).
- Impaired daily function was reported by 36% but not associated with objective cognitive performance.
Conclusions:
- Cognitive impairment is prevalent in liver transplant recipients >1 year post-transplant.
- Below-expectation cognition is associated with increased psychiatric distress.
- Longitudinal assessment of cognitive and mental health is crucial for liver transplant recipients.
Related Concept Videos
01:16Kidney Transplant III: Nursing Management
83
Postoperative Nursing Management for Kidney Transplant PatientsPostoperative nursing management care includes monitoring the surgical site, encouraging early movement, and promoting lung health through breathing exercises. Nurses also administer prescribed medications like H2-blockers, such as famotidine, or proton pump inhibitors, like omeprazole, to help prevent gastrointestinal ulcers and bleeding. Fungal infections in the mouth and bladder can result from immunosuppressive and antibiotic...
83
01:30Negative and Cognitive Symptoms of Schizophrenia
125
Negative symptoms of schizophrenia indicate a reduction or absence of typical behaviors and emotional responses found in healthy individuals, while positive symptoms reflect an excess or distortion of normal functioning.
Negative Symptoms
Negative symptoms of schizophrenia manifest as deficits in normal emotional and behavioral functioning, profoundly impacting daily life. Individuals with schizophrenia often display a flat affect, characterized by a near-total absence of emotional expression,...
Negative Symptoms
Negative symptoms of schizophrenia manifest as deficits in normal emotional and behavioral functioning, profoundly impacting daily life. Individuals with schizophrenia often display a flat affect, characterized by a near-total absence of emotional expression,...
125
01:28Esophageal Varices-II: Clinical Features and Management
145
Esophageal varices often manifest as gastrointestinal bleeding episodes, presenting symptoms like hematemesis (vomiting of blood), hematochezia (passing fresh blood via the rectum), and melena (black, tarry stools). Other signs can include weight loss, anorexia, abdominal discomfort, jaundice, pruritus, altered mental status, and muscle cramps.
In the initial assessment, a thorough review of the patient's medical history is vital to identify risk factors such as liver disease, alcohol...
In the initial assessment, a thorough review of the patient's medical history is vital to identify risk factors such as liver disease, alcohol...
145
01:28Kidney Transplant I: Introduction
60
A kidney transplant is a surgical approach that involves replacing a non-functioning kidney with a healthy one from a donor. This procedure is often a treatment option for end-stage renal disease (ESRD) patients. The method requires careful recipient selection, including evaluating various medical and psychosocial factors. These criteria vary between transplant centers but generally include assessments of the patient's overall health, adherence to medical recommendations, and lifestyle...
60
01:03Long-term Depression
2.6K
Long-term depression, or LTD, is one of the ways by which synaptic plasticity—changes in the strength of chemical synapses—can occur in the brain. LTD is the process of synaptic weakening that occurs over time between pre and postsynaptic neuronal connections. The synaptic weakening of LTD works in opposition to synaptic strengthening by long-term potentiation (LTP) and together are the main mechanisms that underlie learning and memory.
Calcium Ion Concentration Mechanism
If over...
Calcium Ion Concentration Mechanism
If over...
2.6K
01:26Psychosis: Goals of Pharmacotherapy
210
Antipsychotic drugs are a crucial treatment method for acute and chronic psychoses, bipolar illness, and behavioral disorders. The selection of these drugs depends on several factors, including the state of the disease, clinical judgment, possible drug interactions, and the patient's sensitivity to adverse effects. In immediate scenarios, such as delirium and dementia, short-term treatment with low doses of high-potency typical or atypical agents can effectively manage symptom exacerbation.
210