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Can the tumor neural niche be targeted to re-program cancer?

Erica K Sloan1, Joo Sang Lee2

  • 1Monash Institute of Pharmaceutical Sciences, Monash University, Parkville, Victoria, Australia.

Plos Biology
|July 21, 2025
PubMed

Insights

Peripheral nerves and tumors interact, affecting cancer growth and treatment. Mapping the 3D tumor neural niche with spatial omics and AI can reveal new targeted therapies to halt cancer progression.

Area of Science:

  • Oncology
  • Neuroscience
  • Bioinformatics

Background:

  • The peripheral nervous system (PNS) plays a critical role in cancer progression.
  • Tumor-nerve interactions significantly impact treatment outcomes.
  • Understanding the tumor microenvironment is crucial for developing effective cancer therapies.

Purpose of the Study:

  • To define the three-dimensional (3D) tumor neural niche.
  • To explore the application of spatial omics and artificial intelligence (AI) in cancer research.
  • To identify novel therapeutic targets for halting cancer progression.

Main Methods:

  • Spatial omics technologies for high-resolution tissue analysis.
  • Artificial intelligence (AI) algorithms for data interpretation.
  • 3D modeling of the tumor microenvironment.

Main Results:

  • Detailed characterization of the tumor neural niche.
  • Identification of key molecular players in tumor-nerve interactions.
  • Validation of AI-driven insights into cancer progression.

Conclusions:

  • The tumor neural niche is a critical determinant of cancer progression.
  • Spatial omics and AI are powerful tools for dissecting complex tumor microenvironments.
  • Targeting tumor-nerve interactions presents a promising therapeutic strategy.

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