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Updated: Jul 6, 2026

Polymalic Acid-based Nano Biopolymers for Targeting of Multiple Tumor Markers: An Opportunity for Personalized Medicine?
Published on: June 13, 2014
Bioinspired Polymeric Nanomedicines with Tumor Extracellular Matrix Anchoring Capability for Prolonged Tumor
Zekai Xiao1,2, Boya Yu1,2, Shuaiqi Shao1
1School of Biomedical Sciences and Engineering, South China University of Technology, Guangzhou International Campus, Guangzhou, Guangdong 511442, P. R. China.
Abstract:
The unsatisfactory delivery efficacy of nanocarriers adversely restricts the therapeutic activity of encapsulated cargoes, and the current strategies, such as ligand decoration, is limited by the tumor heterogeneity of patients. Inspired by the excellent adhesion behavior of mussels, we developed a nanocarrier (Ac-NP) of catechol-decorated hyperbranched polyglycerol (HPG) to enable strong anchoring to ECM components (collagen I, laminin, proteoglycans), markedly improving the delivery efficacy of various anticancer agents. Meanwhile, to minimize its nonspecific ECM anchoring following intravenous injection, the nanocarrier was masked by 4-carboxyphenylboronic acid (PBA), and the resultant TAc-NPs exhibited specific tumor extracellular ECM-anchoring capability. TAc-NPs showed a 2.3-fold increase in tumor accumulation, with over 70% retained in the ECM. This ECM-anchored system significantly enhanced the therapeutic efficacy of extracellular (BB94), intracellular (doxorubicin), and membrane-targeted (BMS-1) drugs for efficient chemoimmunotherapy. Our strategy offers a broadly applicable nanoplatform for delivery of various types of anticancer agents without the limitation of tumor heterogeneity.
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