Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Concept Videos

Ribosome Profiling02:24

Ribosome Profiling

3.6K
Ribosome profiling or ribo-sequencing is a deep sequencing technique that produces a snapshot of active translation in a cell. It selectively sequences the mRNAs protected by ribosomes to get an insight into a cell’s translation landscape at any given point in time.
Applications of ribosome profiling
Ribosome profiling has many applications, including in vivo monitoring of translation inside a particular organ or tissue type and quantifying new protein synthesis levels.
The technique...
3.6K

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Precision medicine in mental health: applications, challenges, and recommendations - CORRIGENDUM.

European psychiatry : the journal of the Association of European Psychiatrists·2026
Same author

Regional, functional and transcriptomic decoding of multidimensional brain structure alterations in obsessive-compulsive disorder.

Nature communications·2026
Same author

Co-expression-based models improve eQTL predictions for transcriptome-wide association studies and highlight new schizophrenia-associated genes.

Nature genetics·2026
Same author

Psychopathy traits and their link to emotion recognition impairments in conduct disorder.

JCPP advances·2026
Same author

Multiscale heterogeneity of atypical functional connectivity in autism.

Nature. Mental health·2026
Same author

Ischemic injury triggers a protective microglial phenotype in models of Aβ pathology.

Journal of neuroinflammation·2026
Same journal

Chlorinated VSLSs Surpass HCFCs in CFC-11-Equivalent Emissions for Ozone Layer Depletion in China.

Nature communications·2026
Same journal

Author Correction: Charge transfer in triphenylamine-tetrazine covalent organic frameworks for solar-driven hydrogen peroxide production.

Nature communications·2026
Same journal

Vegetation browning patterns under compound soil and atmospheric dryness in northern permafrost ecosystems.

Nature communications·2026
Same journal

Voltage imaging of CA1 pyramidal cells and SST+ interneurons reveals stability and plasticity mechanisms of spatial firing.

Nature communications·2026
Same journal

Radical-omics reveals the hydrogen-abstraction pathway of isoprene oxidation.

Nature communications·2026
Same journal

Toughening elastomer via sequentially activated multi-pathway energy dissipation.

Nature communications·2026
See all related articles

Related Experiment Video

Updated: Sep 14, 2025

Author Spotlight: Cost-Effective Transcriptomic Drug Screening - Unlocking New Targets
06:40

Author Spotlight: Cost-Effective Transcriptomic Drug Screening - Unlocking New Targets

Published on: February 23, 2024

1.4K

Transcriptomic decoding of surface-based imaging phenotypes and its application to pharmacotranscriptomics.

Christine Ecker1,2,3, Charlotte M Pretzsch4, Johanna Leyhausen5,6,7

  • 1Department of Child and Adolescent Psychiatry, University Hospital of the Goethe University, Frankfurt am Main, Germany. ecker@med.uni-frankfurt.de.

Nature Communications
|July 21, 2025
PubMed
Summary
This summary is machine-generated.

This study introduces a new framework linking brain imaging patterns to gene expression for CNS drug discovery. It decodes neurotransmission systems and connects specific GABA A receptor patterns to behaviors, paving the way for targeted therapies.

More Related Videos

Cell Surface Receptor Identification Using Genome-Scale CRISPR/Cas9 Genetic Screens
08:49

Cell Surface Receptor Identification Using Genome-Scale CRISPR/Cas9 Genetic Screens

Published on: June 6, 2020

14.8K
An Antibody Feeding Approach to Study Glutamate Receptor Trafficking in Dissociated Primary Hippocampal Cultures
08:13

An Antibody Feeding Approach to Study Glutamate Receptor Trafficking in Dissociated Primary Hippocampal Cultures

Published on: August 2, 2019

5.8K

Related Experiment Videos

Last Updated: Sep 14, 2025

Author Spotlight: Cost-Effective Transcriptomic Drug Screening - Unlocking New Targets
06:40

Author Spotlight: Cost-Effective Transcriptomic Drug Screening - Unlocking New Targets

Published on: February 23, 2024

1.4K
Cell Surface Receptor Identification Using Genome-Scale CRISPR/Cas9 Genetic Screens
08:49

Cell Surface Receptor Identification Using Genome-Scale CRISPR/Cas9 Genetic Screens

Published on: June 6, 2020

14.8K
An Antibody Feeding Approach to Study Glutamate Receptor Trafficking in Dissociated Primary Hippocampal Cultures
08:13

An Antibody Feeding Approach to Study Glutamate Receptor Trafficking in Dissociated Primary Hippocampal Cultures

Published on: August 2, 2019

5.8K

Area of Science:

  • Neuroscience
  • Genomics
  • Pharmacology

Background:

  • Imaging transcriptomics links brain imaging phenotypes to genetics.
  • Its application in central nervous system (CNS) drug discovery is underexplored.
  • A framework is needed to connect neuroimaging with the brain's transcriptome.

Purpose of the Study:

  • To develop an analytical framework for transcriptomic decoding of neuroimaging patterns.
  • To link imaging-derived phenotypes (IDPs) to the transcriptome of neurotransmission systems in vivo.
  • To explore the potential of this approach for CNS drug discovery.

Main Methods:

  • Utilized spatially-dense human brain transcriptome data.
  • Developed a framework for surface-based neuroimaging pattern decoding.
  • Validated the approach using Positron Emission Tomography (PET) data.
  • Analyzed cortical gene expression profiles of GABA A receptor subunits.

Main Results:

  • Successfully linked IDPs to the transcriptomic landscape of neurotransmission systems.
  • Validated the framework against molecular targets with high gene expression-protein binding correspondence.
  • Dissected two distinct classes of GABA A receptor subunits based on cortical expression patterns.
  • Connected these receptor patterns to specific behavioral symptoms and traits.

Conclusions:

  • The developed framework enables in vivo pharmacotranscriptomics.
  • This approach can guide the development of targeted pharmacotherapies.
  • It offers a pathway for personalized interventions in CNS disorders.