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Updated: Sep 14, 2025

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[Translated article] Hyperhidrosis, Anticholinergics, and Dementia.

J Del Boz1, J C Bautista Vidal2

  • 1Servicio de Dermatología, Hospital Regional Universitario de Málaga, Málaga, Spain.

Actas Dermo-Sifiliograficas
|July 22, 2025
PubMed
Summary
This summary is machine-generated.

Oral anticholinergics effectively treat hyperhidrosis but may be linked to dementia risk. This review examines the controversial connection between anticholinergic use for hyperhidrosis and dementia development.

Keywords:
AnticholinergicsAnticolinérgicosDemenciaDementiaHiperhidrosisHyperhidrosisOxibutininaOxybutynin

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Area of Science:

  • Neurology
  • Pharmacology
  • Dermatology

Background:

  • Oral anticholinergics are widely used off-label for hyperhidrosis treatment, with demonstrated efficacy and a generally favorable safety profile.
  • Recent research links anticholinergic use, particularly in the elderly, to an increased risk of dementia.
  • Some studies suggest hyperhidrosis itself could be an early indicator of dementia.

Purpose of the Study:

  • To investigate the potential association between oral anticholinergic use for hyperhidrosis and the development of dementia.
  • To review current data on this controversial and under-researched topic.

Main Methods:

  • Review of existing studies and clinical trial data on anticholinergic use for hyperhidrosis.
  • Analysis of research associating anticholinergic medications with dementia risk.
  • Examination of studies proposing hyperhidrosis as a potential early symptom of dementia.

Main Results:

  • Evidence supports the effectiveness and safety of oral anticholinergics for hyperhidrosis.
  • Numerous studies link anticholinergic use to dementia, especially in older populations.
  • No specific research has directly connected anticholinergic treatment for hyperhidrosis to dementia development.

Conclusions:

  • The potential link between anticholinergic use for hyperhidrosis and dementia remains an area requiring further investigation.
  • Clinicians should consider the potential risks and benefits when prescribing anticholinergics for hyperhidrosis, particularly in at-risk populations.