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Updated: Sep 14, 2025
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Microdissection of Mouse Brain into Functionally and Anatomically Different Regions
Published on: February 15, 2021
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Dissection of Neurochemical Pathways Across Complexity and Scale
Alice Abbondanza1,2, Nawon Kim3,4,5, Ricardo A S Lima-Filho6
1Laboratory of Neurochemistry, Institute of Physiology of the Czech Academy of Sciences, Prague, Czech Republic.
Journal of Neurochemistry
|July 22, 2025
Summary
Neurochemistry research uses advanced models and tools to explore brain function across species. These innovations offer new insights into central nervous system (CNS) disorders and potential treatments.
Area of Science:
- Neuroscience
- Biochemistry
- Genetics
Background:
- Neurochemistry has long sought to elucidate brain mechanisms from molecular to organismal levels.
- Technological progress has enhanced visualization and understanding of central nervous system (CNS) cellular functions.
Purpose of the Study:
- To review novel models and tools enabling new research questions in Neurochemistry.
- To discuss the advantages and disadvantages of various in vivo and in vitro models for studying neurochemical events.
Main Methods:
- Evaluation of in vivo models (e.g., C. elegans, D. melanogaster, R. norvegicus, M. musculus) and in vitro models (primary cells, iPSCs, immortalized cells).
- Integration of advanced genetic manipulation techniques (CRISPR-Cas9, viral vectors) with imaging modalities (super-resolution microscopy, biosensors).
Main Results:
- Technological advancements facilitate deeper investigation into neurochemical events.
- Novel models and tools provide insights into CNS cellular processes in both health and disease.
Conclusions:
- Cutting-edge technologies enhance the study of neurochemical events in physiological and pathological conditions.
- These advancements pave the way for developing novel therapeutic strategies, including cell and gene therapies, for neurological disorders.
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