Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Concept Videos

Urinary Bladder01:23

Urinary Bladder

1.5K
The urinary bladder is a hollow, muscular sac that temporarily stores urine before it is expelled from the body. It can hold approximately 600 mL of urine prior to micturition. The bladder is retroperitoneal and located behind the pubic symphysis in the pelvic floor.
In males, the bladder is situated in front of the rectum, while in females, it is positioned anterior to the vagina and uterus. The bladder floor contains an inverted triangular area called the trigone, defined by the two ureteric...
1.5K

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Assessment of work-related musculoskeletal pain in urologic microsurgeons.

International journal of impotence research·2026
Same author

Testosterone therapy for female sexual dysfunction: a systematic review of the literature demonstrating outcomes in premenopausal and postmenopausal women.

The journal of sexual medicine·2026
Same author

Access without approval: state-level determinants of peptide availability in sexual medicine.

Sexual medicine·2026
Same author

Impact of testosterone therapy and hypogonadism on treatment outcomes in Peyronie's disease: a multicenter retrospective analysis of collagenase clostridium histolyticum therapy.

The journal of sexual medicine·2026
Same author

The contemporary academic landscape of penile prosthesis surgery: a bibliometric analysis.

The journal of sexual medicine·2026
Same author

Female sexual dysfunction: lack of change in physician practice patterns over time.

Gynecology and pelvic medicine·2026

Related Experiment Video

Updated: Sep 14, 2025

The Use of Cystometry in Small Rodents: A Study of Bladder Chemosensation
08:08

The Use of Cystometry in Small Rodents: A Study of Bladder Chemosensation

Published on: August 21, 2012

22.9K

Toward Novel Targeted Therapy for Overactive Bladder: A Cadaver Study Identifying Critical Autonomic Nerve

Gamal Ghoniem1, Mickey Karram2, Muhammed A M Hammad1

  • 1Department of Urology, University of California, Irvine, California, USA.

Neurourology and Urodynamics
|July 22, 2025
PubMed
Summary

This study identified a high nerve density zone in the anterior vaginal wall, crucial for targeted radiofrequency (RF) therapy in overactive bladder (OAB) treatment. This finding supports minimally invasive RF applications for improved OAB symptom control.

Keywords:
autonomic nerves for female genitourinary systemfemale neuroanatomyoveractive bladderradiofrequencysacral neuromodulationvaginal radiofrequency ablation

More Related Videos

An Orthotopic Bladder Tumor Model and the Evaluation of Intravesical saRNA Treatment
08:43

An Orthotopic Bladder Tumor Model and the Evaluation of Intravesical saRNA Treatment

Published on: July 28, 2012

14.9K
Evaluation of Biomaterials for Bladder Augmentation using Cystometric Analyses in Various Rodent Models
10:19

Evaluation of Biomaterials for Bladder Augmentation using Cystometric Analyses in Various Rodent Models

Published on: August 9, 2012

19.4K

Related Experiment Videos

Last Updated: Sep 14, 2025

The Use of Cystometry in Small Rodents: A Study of Bladder Chemosensation
08:08

The Use of Cystometry in Small Rodents: A Study of Bladder Chemosensation

Published on: August 21, 2012

22.9K
An Orthotopic Bladder Tumor Model and the Evaluation of Intravesical saRNA Treatment
08:43

An Orthotopic Bladder Tumor Model and the Evaluation of Intravesical saRNA Treatment

Published on: July 28, 2012

14.9K
Evaluation of Biomaterials for Bladder Augmentation using Cystometric Analyses in Various Rodent Models
10:19

Evaluation of Biomaterials for Bladder Augmentation using Cystometric Analyses in Various Rodent Models

Published on: August 9, 2012

19.4K

Area of Science:

  • Urology
  • Neuroscience
  • Anatomy

Background:

  • Overactive bladder (OAB) affects numerous individuals, impacting quality of life.
  • Current treatments for OAB include pharmacotherapy and behavioral interventions, with varying efficacy.
  • Targeted radiofrequency (RF) therapy presents a promising minimally invasive approach for OAB management by modulating autonomic nerve pathways.

Purpose of the Study:

  • To identify areas of high nerve density within the bladder and anterior vaginal wall (AVW) in cadaveric specimens.
  • To determine optimal anatomical targets for minimally invasive RF therapy delivery through the anterior vaginal wall for OAB treatment.

Main Methods:

  • Cadaveric anterior vaginal wall (AVW) samples were analyzed using Hematoxylin and eosin (H&E) and S100 immunohistochemistry.
  • Nerve distribution, size, and density were quantified in the bladder and AVW using image analysis software.
  • Statistical analyses (ANOVA, t-tests) compared nerve characteristics across different depths and regions of the posterior bladder wall.

Main Results:

  • S100 staining revealed significantly higher nerve density and larger nerve sizes in the "High nerve density" (HND) region (4.8-7.2 mm depth) of the posterior bladder wall compared to other regions.
  • The HND zone demonstrated the greatest nerve density and largest nerve size across both analyzed cadaveric specimens.
  • Statistical analysis confirmed significant differences (p < 0.05) in nerve size and density within the HND region.

Conclusions:

  • The identified high nerve density (HND) zone in the posterior bladder wall is a critical target for radiofrequency (RF) therapy.
  • Precise application of RF energy to this HND zone, delivered via the anterior vaginal wall, can enhance neuromodulation for OAB.
  • This research supports the development of targeted RF therapy as a minimally invasive and potentially more effective treatment modality for overactive bladder.