Strategies for optimization of hypoglycemia rat models

This review focuses on rat models for studying the short-term and long-term effects of mild and severe hypoglycemia. We explored the physiological mechanisms to understand the consequences of hypoglycemia in rat experimental models. This study aims to investigate the therapeutic potential of phytotherapeutic agents and their efficacy in mitigating the adverse effects of hypoglycemia. Insights from our planned research will be beneficial in improving quality of life for individuals at risk of episodes of low blood sugar. Optimizing hypoglycemic rat models for research requires selecting a suitable experimental model that will be susceptible to hypoglycemia induction, effective monitoring of blood glucose levels, and maintaining a high survival rate throughout the required experimental duration.