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Updated: Sep 14, 2025

Preparation of N-2-alkoxyvinylsulfonamides from N-tosyl-1,2,3-triazoles and Subsequent Conversion to Substituted Phthalans and Phenethylamines
Published on: January 3, 2018
Rhodium-Catalyzed Regio- and Enantioselective Synthesis of Conjugated Enynyl Amines
1Shanghai Key Laboratory for Molecular Engineering of Chiral Drugs, School of Chemistry and Chemical Engineering, Shanghai Jiao Tong University, 800 Dongchuan Road, Shanghai 200240, China.
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Conjugated enynes are versatile synthetic intermediates. However, the synthesis of chiral conjugated enynes is still challenging. A highly regio- and enantioselective synthesis of conjugated enynyl amines from racemic enynyl phosphates and various amines has been developed. Up to 20:1 branch/linear ratio and 99% ee could be obtained in the presence of Rh complexes. The chiral bisoxazolinephosphine (NPN*) ligands play the key role in controlling the chemo- and stereochemistry in this transformation.
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