Related Experiment Video
Updated: Sep 14, 2025

Author Spotlight: Unveiling the Connection Between Sleep Disorders and Cognitive Symptoms in Depression
Published on: April 26, 2024
Fatigue and its correlation with anxiety and depression in patients with multiple sclerosis in China
Han Wang1,2, Rongrong Wang1,2, Runze Zhao3
1Department of Neurology, Yan'an University Medical College No. 3 Affiliated Hospital, Xianyang, China.
Background:
Multiple Sclerosis (MS) is a chronic, progressive, immune-mediated disease of the central nervous system. Fatigue is a common and disabling symptom in patients with MS (PwMS). Some psychological factors, such as depression, stress, and anxiety, also appear to be related to these issues.
Objectives:
The study aimed to investigate the fatigue conditions of PwMS in China and its influencing factors, as well as to explore the correlation between fatigue with anxiety and depression.
Methods:
This study was a cross-sectional study conducted through the Internet, which collected demographic characteristics, clinical data, Modified Fatigue Impact Scale (MFIS), Beck Anxiety Inventory (BAI), and Beck Depression Inventory-II (BDI-II).
Results:
A total of 366 PwMS were included in this study. MFIS showed a median fatigue total score of 40.0 (interquartile range [IQR] 26.0-52.0), with 55.7% (n = 204) of patients experiencing fatigue. The scores on MFIS were positively correlated with age, disease duration, BAI score, and BDI-II score.
Conclusion:
The prevalence of fatigue among Chinese PwMS is 55.7%. Age, education, employment, marital status, type of disease, and disease duration are all factors influencing the fatigue rate in PwMS. Fatigue in PwMS exhibit strong positive correlations with depression and anxiety.
More Related Videos
04:24Acupoint Application as a Traditional Chinese Medicine Treatment for Fatigue Associated with Chronic Obstructive Pulmonary Disease
Published on: September 5, 2025
05:38The Effect of Anti-Fatigue Decoction on the Behaviors and Serological Indicators in a Central Fatigue Rat Model
Published on: April 12, 2024
Related Concept Videos
Generalized Anxiety Disorder
Stress and Mental Health
Individuals with depression often experience challenges in both their personal and professional...
Anxiety: Overview
Individuals with anxiety often experience a range of physical and emotional symptoms, including sweating, trembling, tachycardia, and disturbances in sleep patterns. These symptoms vary in intensity and frequency but are generally disruptive and distressing.
Fatigue
Long-term Depression