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High resolution diffusion imaging in the unfixed post-mortem infant brain at 7T.

Wenchuan Wu1, Sebastian W Rieger2, Luke Baxter1,3

  • 1Wellcome Centre for Integrative Neuroimaging, FMRIB, Nuffield Department of Clinical Neurosciences, University of Oxford, Oxford, United Kingdom.

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|July 22, 2025
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Summary
This summary is machine-generated.

High-resolution diffusion MRI of unfixed infant brains is now possible post-mortem. This technique allows detailed study of brain development without organ donation, overcoming previous technical challenges.

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Area of Science:

  • Neuroimaging
  • Developmental Neuroscience
  • Biomedical Engineering

Background:

  • Diffusion MRI is crucial for studying infant brain development and white matter maturation.
  • Post-mortem imaging offers high resolution but traditionally focused on fixed tissues.
  • Scanning unfixed tissue presents challenges like thermal degradation and energy deposition.

Purpose of the Study:

  • To develop and optimize a protocol for high-resolution post-mortem diffusion MRI of unfixed neonatal brain tissue.
  • To address technical challenges associated with scanning unfixed tissue at ultra-high magnetic field strengths.
  • To enable non-organ donation post-mortem studies of the developing human brain.

Main Methods:

  • Detailed scan setup, protocol optimization, and tissue protection strategies were employed.
  • Utilized ultra-high magnetic field strength with specific considerations for energy deposition.
  • Acquired data from a neonate within the Developing Human Connectome Project (dHCP) cohort.

Main Results:

  • Demonstrated high-quality, high-resolution diffusion MRI data acquisition from unfixed neonatal brain tissue.
  • Observed diffusion properties consistent with known post-mortem changes.
  • Preliminary analyses showed comparability with in vivo data, validating the approach.

Conclusions:

  • High-quality, high-resolution post-mortem diffusion MRI of unfixed neonatal brain tissue is feasible.
  • This technique advances the study of early brain development without requiring organ donation.
  • The developed methods provide a valuable tool for exploring the developing human connectome.