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Platelets in infection: intrinsic roles and functional outcomes
Yuwei Hu1,2, Shuchang Dai1,2, Congchao Qiao1,2,3
1Clinical Transfusion Research Center, Institute of Blood Transfusion, Chinese Academy of Medical Sciences & Peking Union Medical College, Chengdu, China.
Frontiers in Immunology
|July 22, 2025
Summary
Platelets are crucial immune cells that fight infections through pathogen capture and neutralization. Their activation orchestrates innate and adaptive immunity, enhancing host defense mechanisms against pathogens.
Area of Science:
- Immunology
- Hematology
- Infectious Diseases
Background:
- Platelets traditionally known for hemostasis and thrombosis.
- Emerging evidence shows platelets as key players in host defense against infection.
Purpose of the Study:
- To review the multifaceted intrinsic roles of platelets in host defense during infection.
- To delineate the beneficial outcomes of platelet activation in combating pathogens.
Main Methods:
- Literature review of studies on platelet functions in infection.
- Analysis of platelet interactions with pathogens and immune cells.
- Examination of platelet-derived antimicrobial mechanisms.
Main Results:
- Platelets exhibit direct pathogen internalization and recognition.
- Platelets release antimicrobial peptides, cytokines, and immunomodulatory extracellular vesicles.
- Platelet activation contributes to pathogen capture, neutralization, and immune response orchestration.
Conclusions:
- Platelets possess diverse intrinsic anti-infective capabilities.
- Platelet-driven immunity is essential for effective host defense during infection.
- Understanding platelet roles offers new therapeutic avenues for infectious diseases.
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