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Related Concept Videos

Drug Delivery: Miscellaneous Routes01:22

Drug Delivery: Miscellaneous Routes

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Drug delivery methods like oral inhalation, nasal sprays, transdermal patches, eye drops, intravitreal injection,  and rectal administration provide localized effects with reduced toxicity.
Oral inhalation and nasal sprays swiftly transfer drugs across the respiratory epithelium's mucosal layer. Inhaled glucocorticoids and bronchodilators directly target lung conditions such as asthma, while fluticasone nasal spray mitigates allergic rhinitis.
Transdermal patches transport drugs...
468

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Polymeric nanoparticles for efficient nose-to-brain delivery.

Marie Bolon1, Maxime Fieux1,2, Claire Monge1

  • 1UMR 5305: Laboratoire de Biologie Tissulaire et d'Ingénierie Thérapeutique, Institut de Biologie et Chimie des Protéines, CNRS/Université Claude Bernard Lyon 1, 7 Passage du Vercors, CEDEX 07, 69367 Lyon, France. sophie.richard@univ-lyon1.fr.

Nanoscale
|July 22, 2025
PubMed
Summary
This summary is machine-generated.

Polymeric nanoparticles offer a promising non-invasive nose-to-brain delivery strategy, bypassing the blood-brain barrier for treating brain disorders. Their customizable design and functionalization enhance drug transport and therapeutic outcomes.

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Area of Science:

  • Nanotechnology
  • Neuroscience
  • Pharmaceutics

Background:

  • Brain disorders impact over a billion people globally, with limited treatment efficacy due to the blood-brain barrier (BBB).
  • Nose-to-brain delivery (NtBD) via intranasal administration offers a non-invasive route to bypass the BBB for direct brain drug transport.
  • Polymeric nanoparticles are gaining attention for NtBD due to their biocompatibility, biodegradability, and tunable properties.

Purpose of the Study:

  • To review the physicochemical characteristics of polymeric nanoparticles for NtBD.
  • To analyze the impact of nanoparticle properties on mucosal adhesion, mucopenetration, and brain targeting.
  • To explore functionalization strategies and evaluation techniques for optimizing nanoparticle-based NtBD.

Main Methods:

  • Review of physicochemical properties (size, charge, surface modification) of polymeric nanoparticles.
  • Analysis of functionalization strategies (mucoadhesive coatings, peptides, ligands) for enhanced delivery.
  • Critical review of in vitro, ex vivo, and in vivo evaluation models for NtBD.

Main Results:

  • Physicochemical properties significantly influence nanoparticle interaction with biological barriers.
  • Functionalization strategies effectively enhance drug stability, residence time, and cellular uptake.
  • Various evaluation models provide insights into transport mechanisms and therapeutic potential.

Conclusions:

  • Polymeric nanoparticles represent a versatile platform for advanced nose-to-brain delivery systems.
  • Rational design and targeted functionalization are key to optimizing nanoparticle performance for brain disease treatment.
  • This review provides a framework for developing next-generation polymeric nanoparticles for NtBD.