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Using Bioluminescent Imaging to Investigate Synergism Between Streptococcus pneumoniae and Influenza A Virus in Infant Mice
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Factors Associated With Pediatric COVID-19 Mortality: A Pediatric Investigators Collaborative Network on Infections

Michael Prodanuk1, Michelle Barton2, Julie Autmizguine3

  • 1Division of Infectious Diseases, Department of Paediatrics, The Hospital for Sick Children, University of Toronto, Toronto, Ontario, Canada.

Journal of the Pediatric Infectious Diseases Society
|July 22, 2025
PubMed

Insights

In children, medical technology dependence and comorbidities increased the risk of death from COVID-19. This outcome was rare, affecting 0.7% of pediatric COVID-19 hospital admissions.

Area of Science:

  • Pediatric critical care medicine
  • Infectious diseases epidemiology

Background:

  • COVID-19 mortality factors in pediatric populations remain incompletely understood.
  • Characterizing risk factors is crucial for improving outcomes in children with COVID-19.

Purpose of the Study:

  • To identify factors associated with mortality in children diagnosed with COVID-19.
  • To compare characteristics between children who died from COVID-19 and those who survived.

Main Methods:

  • A Canadian-Caribbean case-control study was conducted.
  • 26 pediatric COVID-19 deaths were matched with 78 pediatric COVID-19 survivors from hospital admissions.

Main Results:

  • Medical technology dependence was significantly associated with increased COVID-19 mortality in children.
  • Multiple comorbidities were also identified as risk factors for fatal COVID-19 outcomes in pediatric cases.
  • The overall mortality rate for pediatric COVID-19 admissions in this cohort was 0.7%.

Conclusions:

  • Specific factors like medical technology dependence and comorbidities are linked to higher COVID-19 mortality risk in children.
  • While rare, understanding these risk factors can inform clinical management and preventive strategies for pediatric COVID-19 cases.

Keywords:
COVID-19childrenmortalitypediatric

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