Related Experiment Video
Updated: Sep 14, 2025
07:50
Establishment of a Clinic-based Biorepository
Published on: May 29, 2017
6.6K
A possible turning point for research governance in the life sciences
1University of Nevada Reno, Compliance and Research Administration, Reno, Nevada, USA.
Msphere
|July 22, 2025
Summary
Executive Order 14292 halts gain-of-function research, creating uncertainty. A new adaptive risk governance model is proposed for future biosecurity challenges.
Area of Science:
- Biosecurity and Biosafety Policy
- Infectious Disease Research Governance
Background:
- Executive Order (EO) 14292, issued May 5, 2025, halted federally funded gain-of-function research.
- The EO rescinded the 2024 Dual Use Research of Concern (DURC) and Pathogens with Enhanced Pandemic Potential (PEPP) policy, aiming to bolster biosafety and biosecurity.
Purpose of the Study:
- To analyze the implications of EO 14292 on the scientific enterprise.
- To propose a framework for navigating biosecurity challenges.
Main Methods:
- Analysis of EO 14292's provisions, including definitions and deadlines.
- Consideration of empirical findings and practitioner insights.
- Development of a risk governance model.
Main Results:
- The EO's vague definitions and tight deadline create a biosecurity policy vacuum and uncertainty.
- Politically charged rhetoric may erode trust and buy-in from the scientific community.
- Existing policies for DURC and PEPP were abruptly rescinded.
Conclusions:
- A tiered, adaptive risk governance model is essential for effective biosecurity.
- This model must be grounded in scientific rigor, operational clarity, and institutional expertise.
- Navigating future biosecurity challenges requires a robust and adaptable policy framework.
Related Concept Videos
01:56Ethics in Research
24.0K
Today, scientists agree that good research is ethical in nature and is guided by a basic respect for human dignity and safety. However, this has not always been the case. Modern researchers must demonstrate that the research they perform is ethically sound.
24.0K
01:03Drug Control Governance: Regulatory Bodies and Their Impact
252
Drug control governance involves the oversight and regulation of pharmaceuticals to ensure their safety and efficacy while preventing illegal drug use and trafficking. Regulatory bodies, including the US Food and Drug Administration (FDA) and the European Union's European Medicines Agency (EMA), play a central role in this process. These agencies evaluate the safety and efficacy of drugs before they can be marketed. They fund clinical trials and assess the benefits and risks associated with...
252
01:23Types of Biopharmaceutical Studies: Controlled and Non-Controlled Approaches
177
Biopharmaceutical studies constitute a vital field aiming to enhance drug delivery methods and refine therapeutic approaches, drawing upon diverse interdisciplinary knowledge. In research methodologies, the choice between controlled and non-controlled studies significantly influences the study's reliability and accuracy.
Non-controlled studies, commonly employed for initial exploration, lack a control group, rendering them susceptible to biases and external influences. In contrast,...
Non-controlled studies, commonly employed for initial exploration, lack a control group, rendering them susceptible to biases and external influences. In contrast,...
177
01:22Ethics and Bioethics
1.6K
Ethics is a philosophical study of moral actions. Ethics attempts to determine what is valuable for individuals and society. It examines the rational justification of moral judgments and analyzes what is morally just, fair, and right. Bioethics is a sub-discipline of applied ethics that analyzes the philosophical, social, and legal issues in life sciences and medicine. Ethical theories serve as a foundation for decision-making and represent the viewpoints from which people seek direction. They...
1.6K
01:28Global Regulatory Systems
74
Global regulatory systems in bacteria enable rapid and coordinated responses to environmental changes by integrating sensory inputs with gene expression, ensuring efficient adaptation to fluctuating conditions. Key global regulatory mechanisms include regulons, two-component systems, sigma factors, and secondary messengers.Regulons and Global RegulatorsA regulon is a collection of genes and operons controlled by a common global regulator. These regulators enable bacteria to prioritize resource...
74
01:25Drug Regulation
1.9K
Drug regulation encompasses the management of drug usage by evaluating its safety and efficacy through assessments conducted by regulatory authorities. Regrettably, the history of drug regulation is marred by several catastrophic events. One such incident is the Elixir Sulfanilamide tragedy, in which the toxic compound diethyl glycol was included in a sweet-tasting medication, leading to numerous fatalities. This event prompted the enactment of the Food, Drug, and Cosmetic Act in 1938. Under...
1.9K