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Updated: Sep 14, 2025

A Microwave-Assisted Direct Heteroarylation of Ketones Using Transition Metal Catalysis
Published on: February 16, 2020
General and versatile electrochemical α-C(sp3)-H amidation for N-Mannich base synthesis
Xinxin Zhao1, Jian Wang1, Jiahui Zheng1
1School of Chemistry and Pharmacy Engineering, Nanyang Normal University, Nanyang, 473061, China. 20222044@nynu.edu.cn.
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A green and versatile electrochemical method for the synthesis of N-Mannich bases through oxidative dehydrogenative cross-coupling is reported. A wide range of primary amides, lactams and phthalimides serve as effective amidation reagents, enabling the α-functionalization of both aromatic and aliphatic tertiary amines with excellent regioselectivity and high efficiency under mild, metal-/oxidant-free conditions. This sustainable approach is characterized by its operational-simplicity, broad substrate compatibility, and exceptional functional group tolerance. The practicality and utility of the method are demonstrated by its easy scalability and late-stage modification of structural complex molecules.
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