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Author Spotlight: Exploring Salidroside's Molecular Mechanisms in Breast Cancer Treatment
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Author Spotlight: Exploring Salidroside's Molecular Mechanisms in Breast Cancer Treatment

Published on: June 9, 2023

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Quercetin as a multi-targeted therapeutic agent in breast cancer: molecular targets and therapeutic potential

Ahmed Hjazi1, Sumaya Nadhim Mohammed2, Munthar Kadhim Abosaoda3

  • 1Department of Medical Laboratory, College of Applied Medical Sciences, Prince Sattam Bin Abdulaziz University, 11942, Al-Kharj, Saudi Arabia.

Medical Oncology (Northwood, London, England)
|July 22, 2025
PubMed

Insights

Quercetin, a plant-derived compound, shows promise in breast cancer treatment by targeting key molecular pathways. It may enhance chemotherapy effectiveness and overcome drug resistance, suggesting its potential as a combinational therapy agent.

Area of Science:

  • Oncology
  • Pharmacology
  • Molecular Biology

Background:

  • Breast cancer presents significant challenges including drug resistance, toxicity, and recurrence.
  • Plant-derived compounds are being explored as alternative therapeutic agents.
  • Quercetin, a dietary flavonol, has demonstrated anti-cancer properties.

Purpose of the Study:

  • To review the molecular mechanisms of quercetin in breast cancer.
  • To explore quercetin's potential in overcoming drug resistance and enhancing chemotherapy.
  • To highlight quercetin's role as a potential combinational therapy agent.

Main Methods:

  • Literature review of existing evidence on quercetin's effects in breast cancer.
  • Analysis of molecular pathways regulated by quercetin, including PI3K/Akt/mTOR, Wnt/β-catenin, JAK/STAT, AMPK, and non-coding RNAs.
  • Synthesis of mechanistic understanding and translational applicability.

Main Results:

  • Quercetin modulates multiple oncogenic signaling pathways crucial for breast cancer progression.
  • Evidence suggests quercetin can potentiate the efficacy of conventional chemotherapies.
  • Quercetin demonstrates potential in suppressing multidrug resistance in breast cancer.

Conclusions:

  • Quercetin exhibits pleiotropic effects in breast cancer pathobiology.
  • Quercetin holds therapeutic potential as a complementary agent in breast cancer treatment.
  • Further research into quercetin-based combinational therapies is warranted.
Keywords:
ApoptosisBreast carcinomaMalignancyQuercetinSignaling pathways

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