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Published on: May 22, 2020
UHRF1 in Immune Regulation and Diseases: Mechanisms and Therapeutic Implications
Tingyue Guo1,2, Yihui Ruan3, Bo Wu1
1Department of Thoracic Surgery, Cancer Hospital of Dalian University of Technology (Cancer Hospital of China Medical University, Liaoning Cancer Hospital & Institute), Shenyang, Liaoning, 110042, People's Republic of China.
Abstract:
As a key epigenetic regulator, E3 ubiquitin-ligase ubiquitin-like containing PHD and RING finger domains 1 (UHRF1) is essential for maintaining genomic stability. The aberrant activation of UHRF1 has been strongly implicated in cancer progression. Emerging evidence indicates that UHRF1 serves as a pivotal orchestrator of immune homeostasis. This review provides an overview of the impact of UHRF1 on both innate and adaptive immunity, highlighting its epigenetic and regulatory roles in the development and function of macrophages, T lymphocytes, and B lymphocytes. Crucially, the protective mechanisms of UHRF1 in autoimmune disorders while concurrently detailing its tumor-promoting functions are dissected. Finally, this review discusses the therapeutic challenges and future perspectives for targeting UHRF1 in autoimmune disorders and cancers.
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