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Primed Mycobacterial Uveitis PMU as a Model for Post-Infectious Uveitis
Published on: December 17, 2021
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Real-world treatment patterns for patients with non-infectious uveitis in Japan: a descriptive study using a
Sentaro Kusuhara1, Koh-Hei Sonoda2, Toshikatsu Kaburaki3
1Division of Ophthalmology, Department of Surgery, Kobe University Graduate School of Medicine, 7-5-1 Kusunoki-Cho, Chuo-Ku, Kobe, 650-0017, Japan. kusu@med.kobe-u.ac.jp.
Journal of Ophthalmic Inflammation and Infection
|July 22, 2025
Summary
Corticosteroids are common for non-infectious uveitis (NIU) in Japan, but other treatments are frequently used for moderate-to-severe cases. Early treatment is crucial as ocular complications, like glaucoma, are more common in the first year.
Area of Science:
- Ophthalmology
- Immunology
- Pharmacology
Background:
- Non-infectious uveitis (NIU) is a group of inflammatory eye conditions that can lead to vision loss.
- Treatment strategies for NIU vary based on severity, with mild cases often managed with topical corticosteroids, while moderate-to-severe cases may require systemic treatments.
Purpose of the Study:
- To investigate real-world treatment patterns for non-infectious uveitis (NIU) in Japan.
- To analyze the utilization of various therapies, including corticosteroids, immunosuppressants, and biologics, for NIU management.
Main Methods:
- Analysis of a large Japanese insurance claims database (October 2016-October 2023).
- Identification of NIU patients using ICD-10 codes and confirmation via ophthalmological examination.
- Utilization of Sankey diagrams to visualize treatment transitions and assessment of ocular complications and surgeries.
Main Results:
- Corticosteroid eye drops were the primary treatment for mild NIU (68.7%).
- Oral corticosteroids (19.0%) and sub-Tenon's injections were common for moderate-to-severe NIU.
- Higher incidence of ocular complications, including glaucoma, was observed in the first year of treatment.
Conclusions:
- Corticosteroids remain a cornerstone of NIU treatment in Japan.
- Multiple treatment modalities are used in conjunction with or as alternatives to topical corticosteroids for moderate-to-severe NIU.
- Findings highlight the complex treatment landscape and potential unmet needs in NIU management.
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