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Waveform distortion for temperature compensation and synchronization in circadian rhythms: An approach based on the
Shingo Gibo1, Teiji Kunihiro2, Tetsuo Hatsuda1,3
1RIKEN Center for Interdisciplinary Theoretical and Mathematical Sciences (iTHEMS), Wako, Japan.
Plos Computational Biology
|July 22, 2025
Summary
Circadian rhythms maintain a stable period despite temperature changes through waveform distortions. These distortions are crucial for temperature compensation and synchronization with daily cycles.
Area of Science:
- * Chronobiology and Systems Biology
- * Theoretical Biophysics
Background:
- * Biological processes often accelerate with rising temperatures.
- * Circadian rhythms exhibit temperature compensation, maintaining a constant period despite temperature fluctuations.
- * Synchronization with the 24-hour light-dark cycle is essential for circadian rhythms.
Purpose of the Study:
- * To theoretically investigate the role of waveform distortions in circadian gene-protein dynamics.
- * To explain temperature compensation and synchronization mechanisms in circadian rhythms.
Main Methods:
- * Theoretical analysis using the Goodwin model.
- * Application of the renormalization group method.
- * Analysis of waveform-period correlations in various oscillator models, including Lotka-Volterra, van der Pol, and a mammalian circadian rhythm model.
Main Results:
- * Analytical demonstration that increasing temperature lengthens the decreasing phase of circadian protein oscillations.
- * Identification of waveform distortions as a mechanism for maintaining a stable circadian period.
- * Confirmation of waveform-period correlation across different oscillatory systems.
Conclusions:
- * Circadian rhythm waveform distortions are fundamental to temperature compensation.
- * Waveform characteristics significantly impact the synchronization range of circadian rhythms.
- * The study provides a coherent explanation for temperature compensation hypotheses.
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