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Characterization of Inflammatory Responses During Intranasal Colonization with Streptococcus pneumoniae
Published on: January 17, 2014
Post-vaccination Streptococcus pneumoniae colonization and respiratory manifestations in children: A prospective
Jaqueline Elisa Verardo Benedetti1, Kauana Pizzutti1, Mariana Preussler Mott1
1Departamento de Epidemiologia e Métodos Diagnósticos, Programa de Pós Graduação Ciências da Saúde, Universidade Federal de Ciências da Saúde de Porto Alegre - UFCSPA, Porto Alegre, Rio Grande do Sul, Brazil.
Insights
Streptococcus pneumoniae colonization did not increase respiratory infections in vaccinated children, except for serotype 6B pneumonia in those under two. This study tracked vaccinated children for one year.
Area of Science:
- Pediatric Infectious Diseases
- Vaccinology
- Microbiology
Background:
- Streptococcus pneumoniae causes significant childhood respiratory infections globally.
- Pneumococcal conjugate vaccines (PCV10, PCV13) aim to reduce disease burden.
- Understanding colonization dynamics post-vaccination is crucial for public health.
Purpose of the Study:
- To evaluate the impact of Streptococcus pneumoniae colonization on infection incidence in vaccinated children.
- To assess the relationship between pneumococcal carriage and respiratory diseases over a one-year follow-up.
Main Methods:
- Prospective cohort study of 225 children (18-59 months) vaccinated with PCV10 or PCV13.
- One-year follow-up including interviews and medical record review.
- Statistical analysis using Poisson regression and Chi-squared/Fisher's exact tests.
Main Results:
- High colonization rate (64.4%) observed; only 2.8% carried vaccine serotypes.
- Male gender was associated with colonization (p=0.05).
- No increased risk for respiratory diseases or antimicrobial use in colonized children, except for serotype 6B and pneumonia in children under 2 (p=0.016).
Conclusions:
- Pneumococcal carriage does not significantly increase respiratory disease incidence in fully vaccinated children.
- Serotype 6B colonization is linked to pneumonia in children under two years old.
- Findings inform vaccination strategies and disease surveillance.
Background:
Streptococcus pneumoniae is considered one of the main agents for pneumonia, meningitis, bacteremia, sinusitis, and acute otitis media (AOM)especially in children under 5 years, and a cause for morbidity and mortality due to respiratory infections worldwide. Our aim was to investigate the influence of Streptococcus pneumoniae colonization in vaccinated children regarding infections in a one-year follow-up.
Methods:
A double-blind, observational, prospective cohort study was conducted on children aged 18-59 months, vaccinated with pneumococcal conjugate vaccine 10 (PCV10) or pneumococcal conjugate vaccine 13 (PCV13). A total of 225 children were monitored, with different dates of entry into the study, which occurred between March 2018 and October 2019 (zero time). At the end of one year, counting from the date of entry, interviews and data collection took place in medical records (end of follow-up). The Poisson regression with robust variance and Chi-squared or Fisher's exact tests were used for qualitative analyses; Mann-Whitney or Friedman tests for quantitative analyses.
Results:
A high colonization rate (64.4%) was observed, with only 2.8% of carriers having a PCV10 vaccine serotype, specifically 6B, as expected. Being male showed association to colonization (p = 0.05). We found that children colonized by pneumococcus do not have an increased risk for respiratory diseases or antimicrobial use. Exception was only observed in cases of serotype 6B colonization, showing association with pneumonia in children under 2 years (p = 0.016).
Conclusion:
Our study reveals that the carriage of Streptococcus pneumoniae does not appear to significantly impact the incidence of respiratory diseases in a fully-vaccinated children population. However, it is noteworthy that a correlation was observed in the occurrence of pneumonia in children under the age of 2 when colonized by serotype 6B.
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