Boron nanodrugs for boron neutron capture therapy

Boron neutron capture therapy (BNCT) is a promising therapeutic method for malignant tumors, capable of selectively killing tumor cells through nuclear reactions at the single-cell level without damaging surrounding normal cells. With the rapid development of nano-delivery systems in recent years, boron nanodrugs have improved the efficiency of intra-tumor boron delivery and enhanced the therapeutic efficacy of BNCT. In this paper, we first review the clinically approved boron drugs and their limitations, followed by highlighting the design strategies of different boron nanodrugs. The discussion conclude with the advantages and limitations of carrier-free boron nanodrugs and boron nanodrugs utilizing carriers.