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Zygote Microinjection for Creating Gene Cassette Knock-in and Flox Alleles in Mice
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Cas12a knockin mice expand the toolbox for in vivo and ex vivo multiplexed genome editing
Filippo Birocchi1, Marcela V Maus1
1Krantz Family Center for Cancer Research, Massachusetts General Hospital, Boston, MA, USA; Cellular Immunotherapy Program, Cancer Center, Massachusetts General Hospital, Boston, MA, USA; Harvard Medical School, Boston, MA, USA.
Developmental Cell
|July 22, 2025
Abstract:
Multiplex genome editing is critical for advancing transformative gene therapies and unraveling complex genetic interactions. In a recent issue of Nature Biomedical Engineering, Tang et al. introduced Cas12a knockin mice, providing a versatile platform for disease modeling and the development of multiplexed therapeutic strategies.
