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Biological potential and mechanisms of Brain-Expressed X-linked family proteins in cancers: an updated review
Pingping Wang1, Ziyan Chen2, Hongyan Zhang3
1School of Pharmaceutical Sciences, The First Affiliated Hospital of Zhejiang Chinese Medical University, Hangzhou, 310053, China; Zhejiang Cancer Hospital, Hangzhou, 310022, China.
Background:
Brain-Expressed X-linked (BEX) family proteins is a relative younger protein family in human being, with limited understanding of its pathophysiological functions in health and disease. So far, The human BEX family consists of five members including BEX1-5, which have highly homologous and different subcellular localization, expression patterns and proteasome degradation. Previous research found that BEX family proteins play an important role in p75NTR signal pathway which closely connected with neuron differentiation and regeneration. In recent ten years, more and more studies have shown that BEX family proteins participate in multiple molecular signaling pathways in cancers, liver diseases, heart diseases et al. These evidences hint that BEX family proteins maybe potential therapeutic targets for multiple diseases.
Aim Of Review:
In this review, we systematically summarize the research progress on the role of BEX family proteins in patients with various cancers. Our goal is to provide new treatments and insights into human cancers. In addition, the underlying mechanisms and potential clinical applications of BEX family proteins involved in various cancers were highlighted.
Key Scientific Concepts Of Review:
The BEX family proteins plays an important role in a variety of biological processes, including inhibiting the proliferation and metastasis of cancer cells, and participating in various biological processes such as cell differentiation, cell proliferation, and cell apoptosis.
Insights
Brain-Expressed X-linked (BEX) proteins are emerging therapeutic targets. This review highlights their roles in inhibiting cancer cell proliferation and metastasis, offering insights for new cancer treatments.
Area of Science:
- Molecular Biology
- Oncology
- Biochemistry
Background:
- The Brain-Expressed X-linked (BEX) protein family, comprising BEX1-5, is relatively understudied in human health and disease.
- These proteins exhibit diverse localization, expression, and degradation patterns, influencing pathways like p75NTR involved in neuronal processes.
- Emerging evidence links BEX proteins to various diseases, including cancers, liver, and heart conditions, suggesting therapeutic potential.
Purpose of the Study:
- To systematically review the role of BEX family proteins in human cancers.
- To provide insights into novel therapeutic strategies for cancer treatment.
- To highlight the mechanisms and clinical applications of BEX proteins in oncology.
Main Methods:
- Systematic literature review.
- Analysis of existing research on BEX protein functions in cancer.
- Synthesis of data on molecular signaling pathways involving BEX proteins.
Main Results:
- BEX family proteins play a significant role in regulating cancer cell proliferation and metastasis.
- They are implicated in diverse biological processes crucial to cancer development, including cell differentiation, proliferation, and apoptosis.
- BEX proteins influence multiple molecular signaling pathways relevant to various cancers.
Conclusions:
- BEX family proteins demonstrate potential as therapeutic targets for various cancers.
- Understanding BEX protein mechanisms can lead to the development of new cancer treatments.
- Further research into BEX proteins may unlock novel clinical applications in oncology.
