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Updated: Sep 14, 2025

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Published on: June 26, 2020
The crosstalk of m6A-modified RNA with DNA damage repair
1Biochemistry Ph.D. Program, Florida International University, 11200 S.W. 8th Street, Miami, FL 33199.
Abstract:
N6-methyladenosine (m6A) is the most abundant epitranscriptomic mark on mRNA and plays crucial roles in gene expression, cell differentiation, stress responses, and cancer and neurodegenerative diseases. Recent studies have further revealed a new role of m6A-modified coding and noncoding RNAs in regulating DNA repair and modulating genome stability. In this review, we first discuss the roles of m6A modification in regulating RNA stability and splicing of DNA repair genes, as well as its roles in guiding DNA repair. We then discuss the crosstalk between m6A-modified RNA and DNA damage and repair, highlighting several outstanding questions.
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