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Interindividual differences of corneal sensitivity. Genetic aspects.

J Draeger, W Schloot, H Wirt

    Ophthalmic Paediatrics and Genetics
    |August 1, 1985
    PubMed
    Summary
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    Corneal sensitivity declines with age, with potential sex-specific variations. Individual anesthetic duration for benoxinate varies greatly, possibly due to genetic factors affecting its metabolism.

    Area of Science:

    • Ophthalmology
    • Neuroscience
    • Pharmacology

    Background:

    • Corneal sensitivity is crucial for ocular health and protective reflexes.
    • Age and sex are known factors influencing physiological parameters.
    • Local anesthetics like benoxinate are commonly used in ophthalmology.

    Purpose of the Study:

    • To investigate age-related changes in corneal sensitivity.
    • To examine potential sex-specific differences in corneal sensitivity.
    • To assess the variability in anesthetic duration of benoxinate and explore underlying reasons.

    Main Methods:

    • Corneal sensitivity was measured in 91 volunteers across different age groups using an electronic optical esthesiometer.
    • The duration of action for the local anesthetic benoxinate was recorded.

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  • Statistical analysis was performed to identify correlations with age, sex, and interindividual variability.

    • Main Results:

    • Corneal sensitivity was found to decrease with advancing age.
    • Evidence suggests potential age and sex-specific differences in corneal sensitivity.
    • Significant interindividual variability was observed in the anesthetic duration of benoxinate.

    Conclusions:

    • Age is a significant factor affecting corneal sensitivity.
    • Genetic factors, potentially related to pseudocholinesterase variants, may explain the variability in benoxinate's anesthetic duration.
    • Further research is warranted to elucidate the precise mechanisms behind these age, sex, and genetic influences.