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Relationship between aggregate index of systemic inflammation and mortality from CCD and malignant neoplasms in diabetic patients

  • 0The Second Affiliated Hospital of Baotou Medical College, Inner Mongolia University of Science and Technology, Baotou, China.
Scientific Reports +

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July 22, 2025

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July 22, 2025

View abstract on PubMed

Summary

This summary is machine-generated.

Elevated aggregate index of systemic inflammation (AISI) in diabetic patients significantly increases mortality risk from cardio-cerebrovascular disease and malignant neoplasms. Higher AISI indicates poorer survival outcomes for individuals with diabetes.

Area Of Science

  • Biomarkers and Disease Outcomes
  • Inflammation and Chronic Disease

Background

  • Systemic inflammation is integral to diabetes pathophysiology.
  • The aggregate index of systemic inflammation (AISI) is a novel biomarker for inflammation assessment.
  • Limited data exist on AISI's association with mortality in diabetic populations.

Purpose Of The Study

  • To investigate the association between AISI and mortality risk.
  • To examine the risk of cardio-cerebrovascular disease (CCD) and malignant neoplasm mortality in diabetic patients with varying AISI levels.

Main Methods

  • Analysis of data from the National Health and Nutrition Examination Survey (NHANES) from 2001-2018.
  • Utilized multivariable-adjusted Cox models, Kaplan-Meier analysis, and restricted cubic spline (RCS) analysis.
  • Conducted subgroup and sensitivity analyses to confirm findings.

Main Results

  • Elevated AISI levels were strongly associated with increased CCD mortality (HR 1.18, 95% CI 1.11-1.26).
  • Elevated AISI levels were strongly associated with increased malignant neoplasm mortality (HR 1.20, 95% CI 1.10-1.30).
  • Higher AISI correlated with reduced survival rates in diabetic patients for both conditions.

Conclusions

  • In adults with diabetes, elevated AISI is a significant predictor of increased mortality risk.
  • Higher systemic inflammation, as indicated by AISI, is linked to poorer outcomes from cardio-cerebrovascular disease and malignant neoplasms in diabetic individuals.

Keywords:

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