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Ocular chrysiasis.

S A McCormick, A G DiBartolomeo, V K Raju

    Ophthalmology
    |October 1, 1985
    PubMed
    Summary
    This summary is machine-generated.

    Gold compounds used for rheumatoid arthritis can cause ocular chrysiasis, affecting the cornea and lens. Higher doses and longer treatment durations increase the risk and severity of these gold deposits.

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    Area of Science:

    • Ophthalmology
    • Rheumatology
    • Pharmacology

    Background:

    • Gold compounds have been used to treat rheumatoid arthritis.
    • Ocular side effects, such as chrysiasis, can occur with gold therapy.

    Purpose of the Study:

    • To investigate the prevalence and characteristics of ocular chrysiasis in patients treated with gold compounds for rheumatoid arthritis.

    Main Methods:

    • Examined 34 patients who received over 1 gram of gold compounds for rheumatoid arthritis.
    • Assessed for corneal and lenticular chrysiasis.

    Main Results:

    • 97% of patients on continuous chrysotherapy showed corneal chrysiasis.
    • Gold deposits were mainly in the posterior cornea, concentrated inferiorly.

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  • 55% of patients with >= 3 years of gold therapy had lenticular chrysiasis.

    • Conclusions:

    • Chrysotherapy for rheumatoid arthritis frequently leads to corneal chrysiasis.
    • Lenticular chrysiasis is more common than previously thought.
    • Gold deposition in the eye likely occurs via the anterior chamber aqueous fluid.