Related Experiment Video
Updated: Sep 14, 2025

Dual Electrophysiological Recordings of Synaptically-evoked Astroglial and Neuronal Responses in Acute Hippocampal Slices
Published on: November 26, 2012
Calcium dynamics in habenular astrocytes regulate active coping within behavioral transitions
Léo Michel1, Denys Osypenko1, Patricia Molina1
1The Department of Fundamental Neuroscience, The University of Lausanne, Lausanne, Switzerland.
Abstract:
Behavioral challenges prompt alternating vigorous and reduced mobility - active, passive coping - that optimize energy investment. Here, we show that disrupting astrocytes calcium signaling in the mouse lateral habenula (LHb) prolongs active coping. This state manifests through calcium elevations in both mouse and zebrafish habenular astrocytes. Presynaptic tracing approaches integrate LHb astrocytes within aversion-related neuronal circuits. Thus, astrocytes regulate state transitions highlighting their computational contribution to behaviors across species.
Related Concept Videos
Feedback Regulation of Calcium Concentration
Various transmembrane receptors, such as G protein-coupled receptors (GPCRs), elicit a response to extracellular signals by increasing cytosolic calcium. Activated GPCRs...
Hypothalamic-Pituitary Axis
Diencephalon: Anatomical Regions
Coping Strategies: Problem Focused
For example, consider a student who struggles to understand their...
Ligand-Gated Ion Channel Receptor: Gating Mechanism
Coping Strategies: Emotion Focused

