Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Concept Videos

Feedback Regulation of Calcium Concentration01:27

Feedback Regulation of Calcium Concentration

3.5K
Calcium is an essential signaling molecule required for various cellular functions. Calcium pumps and ion channels on cell and organellar membranes, such as those on the endoplasmic reticulum (ER), regulate calcium concentrations inside the cell. They remain closed, keeping the cytosolic calcium levels low at a resting state.
Various transmembrane receptors, such as G protein-coupled receptors (GPCRs), elicit a response to extracellular signals by increasing cytosolic calcium. Activated GPCRs...
3.5K
Hypothalamic-Pituitary Axis01:37

Hypothalamic-Pituitary Axis

61.7K
The response to stress—be it physical or psychological, acute or chronic—involves activation of the Hypothalamic-Pituitary-Adrenal (HPA) axis. The HPA axis is part of the neuroendocrine system because it involves both neuronal and hormonal communication. Its function is to regulate homeostatic systems—metabolic, cardiovascular, and immune—providing the necessary means to respond to a stressor.
61.7K
Diencephalon: Anatomical Regions01:30

Diencephalon: Anatomical Regions

2.9K
The diencephalon, etymologically translated as 'through brain,' plays an integral role as the conduit between the cerebrum and the vast extent of the nervous system. However, the olfactory system is an exception, as it interfaces directly with the cerebrum. The diencephalon, deeply ensconced beneath the cerebrum, primarily consists of three paired structures — the thalamus, hypothalamus, and epithelamus. It also includes accessory structures such as the subthalamus, which houses the...
2.9K
Coping Strategies: Problem Focused01:27

Coping Strategies: Problem Focused

148
Coping strategies are methods people use to manage, tolerate, or reduce the effects of stressors. These strategies involve both behavioral and psychological actions to handle stressful situations. One common approach is problem-focused coping, which aims to change or eliminate the source of stress rather than merely addressing its consequences. This method involves taking direct action to resolve the issue causing stress.
For example, consider a student who struggles to understand their...
148
Ligand-Gated Ion Channel Receptor: Gating Mechanism01:30

Ligand-Gated Ion Channel Receptor: Gating Mechanism

2.6K
Ligand-gated ion channels are transmembrane proteins that play a vital role in intercellular communication and functions of the nervous system. They allow the influx of ions across the membrane once the neurotransmitter binds, allowing the subsequent transmission of electrical excitation across the neurons. Other ligand-gated ion channels, like the γ-aminobutyric acid (GABA) receptor, permit anions like chloride into the cells on the binding of the GABA molecule. Their entry into the cell...
2.6K
Coping Strategies: Emotion Focused01:20

Coping Strategies: Emotion Focused

149
Emotion-focused coping refers to a set of strategies aimed at managing the emotional impact of stressors, rather than directly addressing their causes. This approach involves altering one's emotional response to stressful situations to reduce their psychological effects. For example, individuals might talk with a friend or engage in activities like journaling to express their feelings. Such actions can help achieve emotional clarity or release, providing the psychological stability needed...
149

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Hierarchical sensory processing in zebrafish thalamocortical-like circuits.

Science (New York, N.Y.)·2026
Same author

Impaired hemostasis in mechanical circulatory support systems: Monitoring with T-TAS® 01, in vitro correction with VWF concentrates, and impact of membrane oxygenators.

Heart & lung : the journal of critical care·2026
Same author

Sepsis Dysregulates Mitochondrial microRNA and Biogenesis in the Diaphragm but Not Limb Muscle.

International journal of molecular sciences·2026
Same author

Diagnostic performance of flow cytometric osmotic fragility testing in hereditary spherocytosis.

Cytometry. Part B, Clinical cytometry·2026
Same author

Deciphering the multi-site phos-code of IRBIT underlying its binding to IP<sub>3</sub>R.

Communications biology·2026
Same author

m-EASIX (better than EASIX) predicts severe CAR T-cell toxicities, worse overall survival, and discriminates cytokine release syndrome from sepsis.

Frontiers in immunology·2026

Related Experiment Video

Updated: Sep 14, 2025

Dual Electrophysiological Recordings of Synaptically-evoked Astroglial and Neuronal Responses in Acute Hippocampal Slices
16:38

Dual Electrophysiological Recordings of Synaptically-evoked Astroglial and Neuronal Responses in Acute Hippocampal Slices

Published on: November 26, 2012

27.5K

Calcium dynamics in habenular astrocytes regulate active coping within behavioral transitions.

Léo Michel1, Denys Osypenko1, Patricia Molina1

  • 1The Department of Fundamental Neuroscience, The University of Lausanne, Lausanne, Switzerland.

Communications Biology
|July 22, 2025
PubMed
Summary

Astrocytes in the brain

More Related Videos

Inducing Plasticity of Astrocytic Receptors by Manipulation of Neuronal Firing Rates
12:47

Inducing Plasticity of Astrocytic Receptors by Manipulation of Neuronal Firing Rates

Published on: March 20, 2014

14.3K
Analyzing the Size, Shape, and Directionality of Networks of Coupled Astrocytes
10:10

Analyzing the Size, Shape, and Directionality of Networks of Coupled Astrocytes

Published on: October 4, 2018

9.0K

Related Experiment Videos

Last Updated: Sep 14, 2025

Dual Electrophysiological Recordings of Synaptically-evoked Astroglial and Neuronal Responses in Acute Hippocampal Slices
16:38

Dual Electrophysiological Recordings of Synaptically-evoked Astroglial and Neuronal Responses in Acute Hippocampal Slices

Published on: November 26, 2012

27.5K
Inducing Plasticity of Astrocytic Receptors by Manipulation of Neuronal Firing Rates
12:47

Inducing Plasticity of Astrocytic Receptors by Manipulation of Neuronal Firing Rates

Published on: March 20, 2014

14.3K
Analyzing the Size, Shape, and Directionality of Networks of Coupled Astrocytes
10:10

Analyzing the Size, Shape, and Directionality of Networks of Coupled Astrocytes

Published on: October 4, 2018

9.0K

Area of Science:

  • Neuroscience
  • Cell Biology
  • Animal Behavior

Background:

  • Behavioral responses involve shifts between active and passive coping strategies to manage energy.
  • The lateral habenula (LHb) is implicated in aversion and behavioral state transitions.

Purpose of the Study:

  • To investigate the role of astrocytes in regulating behavioral coping strategies.
  • To determine if astrocyte calcium signaling in the LHb influences active coping.

Main Methods:

  • Disruption of astrocyte calcium signaling in the mouse lateral habenula (LHb).
  • Calcium imaging in astrocytes of mice and zebrafish.
  • Presynaptic tracing techniques to map neuronal circuits.

Main Results:

  • Disrupting LHb astrocyte calcium signaling prolonged active coping behaviors.
  • Elevated astrocyte calcium signals were observed in the habenula of both mice and zebrafish during active coping.
  • Astrocytes were integrated into aversion-related neuronal circuits.

Conclusions:

  • Astrocyte calcium signaling in the LHb is crucial for regulating transitions between active and passive coping.
  • Astrocytes play a computational role in behavior across species.
  • These findings highlight astrocytes as key regulators of behavioral states.