Significant association between systemic immune-inflammation index and stroke.

Area of Science:

• Cardiovascular Health
• Immunology
• Epidemiology

Background:

• The systematic immune-inflammation index (SII) reflects systemic inflammation.
• Stroke remains a leading cause of disability and mortality.
• Understanding inflammatory markers' role in stroke is crucial.

Purpose of the Study:

• To examine the association between SII and stroke incidence in US adults.
• To identify potential sex-based differences in this relationship.

Main Methods:

• Utilized data from the National Health and Nutrition Examination Survey (2011-2020).
• Calculated SII using platelet, neutrophil, and lymphocyte counts.
• Employed weighted multivariate logistic regression and subgroup analyses.

Main Results:

• Elevated SII levels were significantly associated with a higher likelihood of stroke.
• This association was particularly pronounced in female participants.
• Results remained stable after adjusting for various confounding factors.

Conclusions:

• Higher SII is a potential indicator of increased stroke susceptibility.
• The findings highlight a sex-specific association, warranting further investigation.
• Future studies should explore SII's role in specific stroke subtypes.