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Related Experiment Video

Updated: Sep 14, 2025

Using Unidirectional Rotations to Improve Vestibular System Asymmetry in Patients with Vestibular Dysfunction
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Causal relationship between cardiovascular diseases and vestibular dysfunction: A 2-sample Mendelian randomization

Huiguo Liu1, Liu Shihan, Luo Wenlong

  • 1Department of Otorhinolaryngology, The Second Affiliated Hospital of Chongqing Medical University, Chongqing, China.

Medicine
|July 23, 2025
PubMed
Summary

Cardiovascular diseases like angina, heart failure, and high blood pressure may causally increase the risk of vestibular dysfunction. This genetic study provides evidence for early screening of at-risk individuals.

Keywords:
Mendelian randomizationcardiovascular diseasesinstrumental variablessingle nucleotide polymorphismsvestibular dysfunction

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Area of Science:

  • Genetics
  • Cardiology
  • Neurology

Background:

  • Observational studies suggest a link between cardiovascular diseases (CVDs) and vestibular dysfunction.
  • The causal mechanisms underlying this association are not well understood.

Purpose of the Study:

  • To investigate the potential causal relationship between multiple CVDs and vestibular dysfunction using Mendelian randomization (MR).
  • To provide genetic insights into the pathological mechanisms connecting cardiovascular health and vestibular function.

Main Methods:

  • Two-sample Mendelian randomization (MR) analysis utilizing large-scale genetic datasets (Genome-Wide Association Study for CVDs and FinnGen database for vestibular dysfunction).
  • Employed inverse variance weighting (IVW), MR-Egger, and weighted median methods.
  • Conducted sensitivity analyses to assess result robustness and reverse MR to test causality in the opposite direction.

Main Results:

  • Genetic evidence supports a causal link between angina pectoris, heart failure, myocardial infarction, high blood pressure, coronary atherosclerosis, and vestibular dysfunction.
  • No significant genetic causality was found between atrial fibrillation and vestibular dysfunction.
  • Reverse MR analysis did not reveal a causal effect of vestibular dysfunction on CVDs.

Conclusions:

  • This study provides the first genetic evidence that several CVDs are risk factors for developing vestibular dysfunction.
  • Findings support early clinical screening for vestibular dysfunction in individuals with CVDs.
  • Further research into the cardiovascular-vestibular axis molecular mechanisms and interventional studies are warranted for clinical translation.