Related Experiment Video
Updated: Sep 14, 2025
Synovial Fluid Analysis to Identify Osteoarthritis
Published on: October 20, 2022
Investigating the association between calcium-phosphorus balance and osteoarthritis: Evidence from NHANES 2007-2016
Junjie Kang1, Suyalatu Xin, Huxiong Zhang
1Department of Orthopedics Ward 1, Ordos Central Hospital, Ordos, Inner Mongolia, China.
Abstract:
The role of the calcium-phosphorus balance in influencing osteoarthritis (OA) risk is not fully understood. This study investigated the relationship between calcium-phosphorus metabolism and OA risk. Data from the National Health and Nutrition Examination Survey spanning 2007 to 2016 were used in this study. Participants aged ≥ 30 years with available serum calcium and phosphorus levels, self-reported OA status, and relevant covariates were included in the study. Multivariable logistic regression analysis was performed to assess the potential influence of calcium-phosphorus metabolism on the risk of OA. Nonlinear relationships were assessed using the restricted cubic spline model. Participants with OA had mildly elevated calcium and phosphorus levels. Concurrently, the calcium-phosphorus (Ca/P) ratio decreased. With confounders adjusted for, the Ca/P ratio was inversely associated with OA risk (odds ratio (OR) = 0.72, 95% CI: 0.56-0.94, P = .017), while serum calcium (OR = 2.12, 95% confidence interval (CI): 0.96-4.68, P = .064) and phosphorus (OR = 1.87, 95% CI: 1.22-2.86, P < .01) were positively associated. The relationship between the Ca/P ratio and risk of OA was significantly influenced by body mass index (P for interaction < .05). The restricted cubic spline model indicated that the Ca/P ratio was nonlinearly associated with OA risk with a threshold of 1.96. Serum calcium level was associated with OA in a U-shaped pattern, with a threshold of 2.35. In contrast, a linear association was observed between serum phosphorus levels. A reduced Ca/P ratio, increased serum phosphorus, and either elevated or decreased serum calcium each contribute to a heightened risk of OA. Imbalances in calcium-phosphorus metabolism may be associated with osteoarthritis risk. Relevant biomarkers, such as serum calcium, phosphorus, and the Ca/P ratio, could serve as potential indicators. Further studies are needed to confirm these findings.
More Related Videos
07:22Glycemic Impact on Knee Osteoarthritis Symptoms on Physical, Radiographic, and Inflammatory Markers among Individuals Aged 50 and Over with Diabetes
Published on: March 7, 2025
06:31Author Spotlight: Enhancing Rheumatoid Arthritis Research Through HR-pQCT Imaging Analysis
Published on: October 6, 2023
Related Concept Videos
01:31Essential Minerals for Bone Health
Calcium and Phosphorus
Calcium is a critical component of bones, especially in the form of calcium phosphate and calcium carbonate. Since the body cannot make calcium, it must be obtained from the diet. However, calcium cannot be absorbed from the small intestine without...
01:29Bone Disorders
Bone deposition is also affected by the levels of sex hormones like estrogen and testosterone that promote osteoblast activity and bone matrix synthesis. When the level of these hormones decreases due to aging, it causes a reduction in bone deposition. As a result, bone resorption by osteoclasts...
01:31Osteoclasts in Bone Remodeling
01:17Hormones and Bone Tissue
Hormones That Influence Osteoblasts and/or Maintain the Matrix
Several hormones are necessary for controlling bone growth and maintaining the bone matrix. The pituitary gland secretes growth hormone (GH), which, as its name implies, controls bone growth. This happens in several ways: first, it triggers chondrocyte...
01:11Genome-wide Association Studies-GWAS
GWAS does not require the identification of the target gene involved in...
01:21Skeleton and Calcium Homeostasis