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Quantitative Analysis of Cellular Composition in Advanced Atherosclerotic Lesions of Smooth Muscle Cell Lineage-Tracing Mice
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Natural Products in Regulating Mitophagy for the Intervention of Atherosclerosis and Its Risk Factors: Mechanisms and

Yu-Han Li1, Hao Ma2, Ying-Rui Wang1

  • 1Shandong University of Traditional Chinese Medicine, Jinan, China.

Phytotherapy Research : PTR
|July 23, 2025
PubMed

Insights

Natural products show promise for treating atherosclerosis (AS) by regulating mitophagy, a cellular process linked to AS and its risk factors. This offers a new avenue for drug development against this global health challenge.

Area of Science:

  • Cardiovascular Research
  • Cellular Biology
  • Pharmacology

Background:

  • Atherosclerosis (AS) is a complex, chronic systemic disease with limited therapeutic options.
  • Current treatments for AS focus on lipid-lowering, anti-inflammatory, and immunotherapies, but new drug targets are urgently needed.
  • Mitophagy, a key cellular process, is increasingly recognized for its role in AS pathogenesis and as a potential therapeutic target.

Purpose of the Study:

  • To review the mechanisms by which natural products (NPs) regulate mitophagy.
  • To explore the therapeutic potential of NPs in alleviating AS and intervening in its risk factors.
  • To discuss the application prospects of NPs for novel drug development in AS treatment.

Main Methods:

  • Literature review focusing on studies investigating natural products, mitophagy, and atherosclerosis.
  • Analysis of the molecular mechanisms linking NP-mediated mitophagy regulation to AS.
  • Evaluation of the therapeutic efficacy and safety profiles of NPs.

Main Results:

  • Natural products exhibit diverse pharmacological activities and lower toxicity, making them attractive candidates for AS intervention.
  • NPs can modulate mitophagy pathways, offering a novel strategy to combat AS.
  • Evidence suggests NPs can alleviate AS progression and mitigate its associated risk factors through mitophagy regulation.

Conclusions:

  • Natural products hold significant therapeutic potential for treating atherosclerosis by targeting mitophagy.
  • Further research into NPs modulating mitophagy could lead to the development of innovative drugs for AS.
  • This review highlights NPs as a promising frontier in the fight against atherosclerosis.
Keywords:
atherosclerosismitophagynatural productsrisk factorstreatment

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