Selected PEAR1 and MRVI1 Gene Polymorphisms in Patients with Migraine and Sticky Platelet Syndrome

One of the most common clinical manifestations of inherited platelet hyperaggregability also known as sticky platelet syndrome (SPS) is migraine. The aim of this study was to assess the role of single nucleotide polymorphisms (SNPs) of platelet endothelial aggregation receptor 1 (PEAR1) and murine retrovirus integration site 1 (MRVI1) genes in pathogenesis of SPS associated with migraine. Hundred patients with SPS and migraine as well as two hundred and seven patients with SPS and without migraine as a control group were enrolled. SPS was diagnosed by light transmission aggregometry (LTA) according to the method and criteria described by Mammen and Bick. Two SNPs within PEAR1 gene (rs12041331 and rs12566888) and two SNPs within MRVI1 gene (rs7940646 and rs1874445) were assessed using High resolution melting (HRM) analysis. Minor allele frequencies for both SNPs within PEAR1 and MRVI1 in patients with SPS and history of migraine as well as haplotypes did not significantly differ compared to the SPS control group. The study also suggests SPS as a complex interaction of several genes resulting in possible polygenic phenotype of migraine in SPS patients.