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Green and Safe Straightforward Coupling of Anhydrides to Ketones and Biphenyls in Quartz Sand Medium
Zujia Lu1,2, Baoying Huang1,2, Guangzao Yang2
1Institute of Chemical Engineering, Guangdong Academy of Sciences, Guangzhou 510665, China.
Abstract:
We present a sustainable and safe method for synthesizing aromatic ketones and biphenyls using quartz sand as a green medium. Quartz sand replaces traditional solvents, providing a safer, eco-friendly alternative in Suzuki-Miyaura coupling and decarbonylative coupling reactions. The Suzuki-Miyaura coupling reactions occur under mild, solvent-free conditions with efficient synthesis and easy purification. Both quartz sand and catalyst are reusable, highlighting the method's resource efficiency and environmental sustainability. Biphenyls are produced via ligand- and copper salt-assisted decarbonylative coupling.
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