Green and Safe Straightforward Coupling of Anhydrides to Ketones and Biphenyls in Quartz Sand Medium
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Updated: Sep 14, 2025

Preparation of Contiguous Bisaziridines for Regioselective Ring-Opening Reactions
Published on: July 28, 2022
Zujia Lu1,2, Baoying Huang1,2, Guangzao Yang2
1Institute of Chemical Engineering, Guangdong Academy of Sciences, Guangzhou 510665, China.
Abstract:
We present a sustainable and safe method for synthesizing aromatic ketones and biphenyls using quartz sand as a green medium. Quartz sand replaces traditional solvents, providing a safer, eco-friendly alternative in Suzuki-Miyaura coupling and decarbonylative coupling reactions. The Suzuki-Miyaura coupling reactions occur under mild, solvent-free conditions with efficient synthesis and easy purification. Both quartz sand and catalyst are reusable, highlighting the method's resource efficiency and environmental sustainability. Biphenyls are produced via ligand- and copper salt-assisted decarbonylative coupling.
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