Related Experiment Video
Updated: Jul 28, 2026
Stereotactic Radiosurgery for Gynecologic Cancer
Published on: April 17, 2012
Intraoperative radiotherapy in the local control of chest wall Ewing sarcoma
S Monje Fuente1, A Del Cañizo López1, J Ordóñez Pereira1
1Pediatric Surgery Department. Hospital Infantil Universitario Gregorio Marañón. Madrid (Spain).
Insights
Intraoperative radiotherapy combined with surgery offers excellent local control for chest wall Ewing sarcoma in pediatric patients. This approach achieved 100% local disease control and high survival rates in a recent study.
Area of Science:
- Pediatric Oncology
- Surgical Oncology
- Radiation Oncology
Background:
- Ewing sarcoma is a rare pediatric malignancy requiring multidisciplinary management.
- The specific role of intraoperative radiotherapy (IORT) in chest wall Ewing sarcoma treatment remains under investigation.
Purpose of the Study:
- To evaluate the efficacy and safety of intraoperative radiotherapy in pediatric patients with chest wall Ewing sarcoma undergoing surgical resection and reconstruction.
Main Methods:
- A retrospective study included 8 pediatric patients (up to 16 years) treated between 2011-2024.
- Data collected included patient demographics, treatment details (neoadjuvant therapy, resection, IORT, reconstruction), complications, and outcomes (local control, survival).
Main Results:
- Complete tumor resection (R0) was achieved in all patients.
- 100% local disease control and an 87.5% overall survival rate were observed at a mean follow-up of 6 years.
- Reconstruction using flexible patches, titanium plates, or muscle flaps was successful, with no flap loss.
Conclusions:
- Intraoperative radiotherapy is a viable treatment option for achieving local control in pediatric chest wall Ewing sarcoma, particularly when large surgical resections are necessary.
- The study highlights the potential of IORT to improve outcomes for this rare cancer.
Introduction:
Ewing sarcoma is a rare malignant tumor with an incidence of 3 cases per 1 million inhabitants annually. Cross-disciplinary management is key to improve survival rates. The role played by intraoperative radiotherapy in terms of treatment is still to be defined.
Material And Methods:
A retrospective study of pediatric patients (up to 16 years of age) with chest wall Ewing sarcoma undergoing tumor resection surgery, intraoperative radiotherapy, and chest wall reconstruction in our institution from 2011 to 2024 was carried out. Variables such as age at surgery, sex, neoadjuvant treatment, resection type, characteristics of intraoperative radiotherapy, reconstruction type, complications, local control rate, relapses, survival, and reconstruction's functional result were collected.
Results:
8 patients were included. Mean age at diagnosis was 12.5 years. Full tumor mass removal with free margins (R0) was achieved in 100% of the cases. Reconstructive techniques with flexible patches, titanium plates, and muscle flaps were used. None of the flaps was lost. Overall survival was 87.5%, with a mean follow-up period of 6 years. 3- and 5-year overall survival rates were 100% and 80%, respectively. Local control of the disease was achieved in 100% of the cases.
Conclusions:
This paper discusses the role of intraoperative radiotherapy as a good treatment alternative to achieve the local control of Ewing sarcoma associated with large surgical resections.
More Related Videos
04:04Endobronchial Ultrasound-guided Intratumoral Injection of Cisplatin for the Treatment of Isolated Mediastinal Recurrence of Lung Cancer
Published on: February 12, 2017
08:54Treatment of Liver Metastases Using an Internal Target Volume Method for Stereotactic Body Radiotherapy
Published on: May 8, 2018
