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Updated: Sep 14, 2025
A Morphometric and Cellular Analysis Method for the Murine Mandibular Condyle
Published on: January 11, 2018
Temporomandibular joint disc position affects condylar bone modeling - a randomized controlled clinical trial
Shijing Yue1, Jiong Zhao1, Siyu Wu1
1Department of Oral Surgery, Shanghai Ninth People's Hospital, Shanghai Jiao Tong University School of Medicine; College of Stomatology, Shanghai Jiao Tong University; National Center for Stomatology; National Clinical Research Center for Oral Diseases; Shanghai Key Laboratory of Stomatology; Shanghai Research Institute of Stomatology; Research Unit of Oral and Maxillofacial Regenerative Medicine, Chinese Academy of Medical Sciences, Shanghai, China.
Anterior disc displacement without reduction in temporomandibular joints restricts condylar bone growth. Disc position directly influences condylar bone modeling and remodeling in young adults.
Area of Science:
- Temporomandibular Joint (TMJ) disorders
- Orthodontics
- Oral and Maxillofacial Surgery
Background:
- The relationship between disc position and condylar adaptation in TMJ anterior disc displacement (ADD) is unclear.
- Long-term effects of ADD on condylar bone remodeling are poorly understood.
Purpose of the Study:
- To evaluate the impact of different disc positions on condylar bone modeling and remodeling.
- To compare condylar volume and height changes in patients with ADDwoR undergoing different treatments.
Main Methods:
- Randomized controlled trial with 60 patients under 25 diagnosed with TMJ ADD without reduction (ADDwoR).
- Patients were assigned to disc displaced (DD) or disc repositioned (DR) groups.
- 3D condylar reconstructions from CT scans analyzed condylar volume and height at baseline and 18-month follow-up.
Main Results:
- The DR group showed a significant increase in condylar volume (279.6 mm3) compared to the DD group (29.5 mm3) after 18 months (p <0.0001).
- Significant differences in condylar height changes were observed between groups, especially at posterolateral and lateral surfaces (p <0.05).
- Disc position correlated with specific patterns of bone resorption and remodeling.
Conclusions:
- ADDwoR significantly restricts condylar bone growth in adolescents and young adults.
- Disc position is a direct determinant of condylar bone modeling and remodeling patterns in this population.
