Integrated strategies for type 2 diabetes prevention: The role of diet and exercise

Type 2 diabetes (T2D) is a prevalent global health problem largely caused by lifestyle factors, including poor diet and physical inactivity. With the increasing incidence of T2D, effective prevention strategies are urgently needed. This review examines the role of different dietary patterns and exercise regimens in the prevention and management of T2D, focusing on their effects on glycemic control, insulin sensitivity, and cardiovascular health.

A narrative review was conducted synthesizing evidence from clinical trials, cohort studies, and meta-analyses. The review focused on the effects of low-carbohydrate diets (LCDs), Mediterranean diets (MDs), plant-based diets, high-protein diets (HPDs), and various exercise regimens, including aerobic, resistance, and high-intensity interval training (HIIT).

Dietary interventions, particularly MD and plant-based diets, are associated with improved glycemic control and reduced risk of developing T2D. LCDs show short-term benefits for weight management and HbA1c reduction, although adherence remains a challenge. HPDs show mixed results, with some benefits for lipid profiles but inconsistent effects on glycemic control. Exercise programs, especially combined aerobic and resistance training, significantly improve glycemic control, insulin sensitivity, and cardiovascular risk factors. HIIT emerges as an effective option for improving metabolic health in individuals at risk for or living with T2D.

A combination of dietary modification and physical activity, particularly Mediterranean and plant-based diets coupled with combined aerobic and resistance exercise, appears to be the most effective strategy for the prevention and management of T2D. Future research should focus on personalized approaches that integrate both diet and exercise to tailor interventions to individual patient needs.