Related Experiment Video

Updated: Sep 14, 2025

In Vivo Mouse Model of Spinal Implant Infection
08:03

In Vivo Mouse Model of Spinal Implant Infection

Published on: June 23, 2020

2.5K

Oral vancomycin is associated with less therapy intensification in adults with symptomatic inflammatory bowel disease

Chiraag Kulkarni1, Sarah Talamantes1, Abhishek Dimopoulos-Verma1

  • 1Division of Gastroenterology and Hepatology, Department of Medicine, Stanford University, Palo Alto, California, USA (Chiraag Kulkarni, Sarah Talamantes, Abhishek Dimopoulos-Verma, Touran Fardeen, Sidhartha R. Sinha).

Annals of Gastroenterology
|July 23, 2025
PubMed
Abstract

Insights

Oral vancomycin therapy (OVT) may reduce the need for inflammatory bowel disease (IBD) therapy intensification in adults with IBD and primary sclerosing cholangitis (PSC). Further research is recommended.

Area of Science:

  • Gastroenterology
  • Hepatology
  • Pharmacology

Background:

  • Limited data exist on oral vancomycin therapy (OVT) effects on adult inflammatory bowel disease (IBD) and primary sclerosing cholangitis (PSC) patients.
  • OVT shows promise for IBD remission in pediatric IBD-PSC patients.

Purpose of the Study:

  • To evaluate the association between OVT and IBD therapy intensification in adults with IBD-PSC.

Main Methods:

  • Retrospective analysis of 22 adult IBD-PSC patients at two centers.
  • Stratified patients by time on and off OVT (minimum 12 months each).
  • Primary outcome: frequency of IBD therapy intensification events.

Main Results:

  • 68.2% of patients had fewer IBD therapy intensification events while on OVT.
  • OVT was associated with significantly fewer therapy intensification events (1.7 vs. 6.7 per 10 person-years, P=0.021).
  • OVT use correlated with fewer steroid prescriptions (0.6 vs. 3.2 per 10 person-years, P=0.013).

Conclusions:

  • Oral vancomycin therapy is linked to a reduced need for IBD therapy escalation in symptomatic adult IBD-PSC patients.
  • Prospective clinical trials investigating OVT in this patient population are warranted.
Keywords:
Inflammatory bowel diseasedisease activityoral vancomycin therapyprimary sclerosing cholangitis

More Related Videos

Fecal Microbiota Transplantation via Colonoscopy for Recurrent C. difficile Infection07:06

Fecal Microbiota Transplantation via Colonoscopy for Recurrent C. difficile Infection

Published on: December 8, 2014

27.2K
Endoscopic Injection Sclerotherapy Assisted by Cyanoacrylate and Clips for Gastroesophageal Varices04:09

Endoscopic Injection Sclerotherapy Assisted by Cyanoacrylate and Clips for Gastroesophageal Varices

Published on: June 13, 2025

347

Related Concept Videos

Inflammatory Bowel Disease IV: Pharmacological Management01:29

Inflammatory Bowel Disease IV: Pharmacological Management

Upon diagnosis, managing Inflammatory Bowel Disease (IBD) involves addressing several crucial aspects. The primary goals include resting the bowel, correcting malnutrition, and providing symptomatic relief. Resting the bowel may consist of medications to reduce inflammation and promote healing. Correcting malnutrition is essential, often requiring dietary adjustments and nutritional supplements. Symptomatic relief aims to ease pain, diarrhea, and other discomforts in IBD.
Pharmacologic...
196
Drugs for Treatment of Ulcerative Colitis in IBD01:29

Drugs for Treatment of Ulcerative Colitis in IBD

Ulcerative colitis is a chronic inflammatory condition primarily affecting the colon and rectum. The primary drugs used in the treatment of ulcerative colitis are aminosalicylates. They exhibit anti-inflammatory and immunosuppressive properties. They modulate inflammatory mediators and inhibit the activity of nuclear factor κB (NF-κB). Aminosalicylates also reduce inflammation by inhibiting prostaglandin and leukotriene production and decreasing neutrophil chemotaxis and superoxide...
239
Drugs for Treatment of Crohn's Disease in IBD Using Immunomodulatory Agents01:29

Drugs for Treatment of Crohn's Disease in IBD Using Immunomodulatory Agents

Crohn's disease is an inflammatory bowel disorder marked by chronic inflammation of the GI tract. Various treatment strategies for Crohn's disease are employed, such as immunomodulatory agents, glucocorticoids, and biologics or anti-TNF therapy. Azathioprine (Imuran), a commonly used immunomodulatory drug for Crohn's disease, is converted in the body to mercaptopurine, which inhibits purine biosynthesis and cell proliferation. Both are utilized in severe cases of Inflammatory Bowel...
271
Drugs for Peptic Ulcer Disease: Sucralfate as Mucosal Protective Agents01:24

Drugs for Peptic Ulcer Disease: Sucralfate as Mucosal Protective Agents

In the intricate landscape of the gastric lumen, excessive acid secretion disrupts the natural defense mechanisms, weakening the mucus-bicarbonate barrier. This vulnerability allows pepsin to infiltrate epithelial cells, digesting mucosal proteins and triggering erosion, leading to ulcer formation.
In this scenario, mucosal protective agents like sucralfate play an essential role. Sucralfate, a complex of sulfated sucrose and aluminum hydroxide, demonstrates its usefulness in acidic conditions,...
699
Inflammatory Bowel Disease III: Diagnostic Studies and Management I-Nutritional Therapy01:30

Inflammatory Bowel Disease III: Diagnostic Studies and Management I-Nutritional Therapy

Various diagnostic tests are employed in the diagnostic process for Inflammatory Bowel Disease (IBD), particularly to differentiate between Crohn's disease and ulcerative colitis.
Diagnostic studies
A colonoscopy is the definitive screening test, distinguishing ulcerative colitis from other colon diseases with similar symptoms. During a colonoscopy test, inflamed mucosa with exudate ulcerations can be observed, and biopsies are taken to determine the histologic characteristics of the...
424
Inflammatory Bowel Disease V: Surgical Management01:21

Inflammatory Bowel Disease V: Surgical Management

Surgical interventions for inflammatory bowel disease (IBD), which includes ulcerative colitis and Crohn's disease, are essential in managing symptoms and addressing complications. The selection of surgical procedures is contingent upon the specific conditions and complications that stem from these illnesses.
Here are some common surgical interventions for IBD:
219