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Updated: Sep 14, 2025

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Published on: July 14, 2023
An innovative compound that promotes oral wound healing via mobilizing gingival mesenchymal stem cell homing
Lei Yang1, Yue Song2, Yao Jiao1
1Laboratory of Tissue Regeneration and Immunology and Department of Periodontics, Beijing Key Laboratory of Tooth Regeneration and Function Reconstruction, School of Stomatology, Capital Medical University, No.9 Fanjiacun Road, Fengtai District, Beijing, 100070, PR China.
Abstract:
Oral wound healing is a complex biological process involving inflammation, proliferation, and tissue remodeling. Gingival mesenchymal stem cells (GMSCs) play a crucial role in this process due to their regenerative potential and immunomodulatory properties. This study investigated whether Purpurolide C (PC), a fungal-derived bioactive compound, could promote oral wound healing by promoting the migratory ability of GMSCs. In vitro, PC enhanced GMSC migration, pluripotency, and osteogenic differentiation. In vivo, a mouse palatal soft tissue defect model demonstrated that PC significantly accelerated wound closure and increased GMSC recruitment to the wound site. Furthermore, 16S rRNA sequencing revealed that PC administration did not disrupt gut microbiota homeostasis. These findings suggest that PC is a promising therapeutic agent for enhancing oral wound healing, paving the way for potential clinical applications in regenerative medicine.
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