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Risk factors for 1-year peripheral neuropathy and F-wave abnormalities after COVID-19: a prospective cohort study
Qian Yang1, Yingying Chang2, Yinuo Zhao3
1Haikou Fourth People's Hospital, Haikou, Hainan, China.
Frontiers in Neurology
|July 23, 2025
Summary
Older age is a risk factor for peripheral neuropathy (PNP) after COVID-19. Higher education is linked to mononeuropathy, a specific type of nerve damage, during rehabilitation.
Area of Science:
- Neurology
- Infectious Diseases
- Rehabilitation Medicine
Background:
- Coronavirus disease 2019 (COVID-19) can lead to long-term neurological complications.
- Peripheral neuropathy (PNP) is a potential post-COVID-19 condition affecting nerve function.
- Understanding risk factors for PNP is crucial for effective rehabilitation strategies.
Purpose of the Study:
- To identify independent risk factors for developing peripheral neuropathy (PNP) in patients undergoing rehabilitation for COVID-19.
- To investigate risk factors associated with F-wave abnormalities, an indicator of nerve damage, in post-COVID-19 patients.
- To explore predictors of mononeuropathy and polyneuropathy within the PNP cohort.
Main Methods:
- Prospective cohort study of 313 COVID-19 patients during a one-year rehabilitation period.
- Multivariable logistic regression analysis was employed to determine independent risk factors.
- Statistical significance was set at p<0.0125 to control for type I error.
Main Results:
- 74% of patients developed PNP within one year of follow-up.
- Older age (OR=1.22) was independently associated with an increased risk of PNP.
- Higher education level (OR=5.07) was significantly associated with mononeuropathy.
Conclusions:
- Age is a potential independent risk factor for peripheral neuropathy following COVID-19.
- Higher educational attainment is linked to an increased likelihood of developing mononeuropathy.
- These findings aid in identifying at-risk individuals for targeted interventions during post-COVID-19 recovery.
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