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Fahr's Syndrome With Neurocognitive Dysfunction Due to Hypoparathyroidism: A Case Report.
Faezeh Sehatpour1, Shahrzad Mohseni1, Mahnaz Pejman Sani1
1Endocrinology and Metabolism Research Center, Endocrinology and Metabolism Clinical Sciences Institute, Tehran University of Medical Sciences, Tehran, Iran.
Case Reports in Endocrinology
|July 23, 2025
Summary
Fahr's syndrome, a rare neurological disorder, can be caused by hypoparathyroidism. Early diagnosis and treatment of low calcium levels are crucial for managing this condition and improving patient outcomes.
Area of Science:
- Neurology
- Endocrinology
- Radiology
Background:
- Fahr's syndrome is a rare neurodegenerative disorder.
- Characterized by progressive calcification of basal ganglia and brain structures.
- Symptoms overlap with other neurological disorders, leading to potential misdiagnosis.
Observation:
- A 68-year-old male presented with declining consciousness and dysarthria.
- Laboratory tests revealed hypocalcemia and low parathyroid hormone.
- Brain imaging confirmed bilateral calcifications in basal ganglia, thalami, and dentate nuclei.
Findings:
- Electrocardiogram (ECG) showed a prolonged QTc interval, indicative of hypocalcemia.
- Intravenous calcium gluconate administration corrected calcium levels and QTc interval.
- Patient's consciousness level improved following treatment.
Implications:
- Hypoparathyroidism should be considered in patients with neurological symptoms and hypocalcemia.
- Early identification and management of hypoparathyroidism are vital.
- Prompt treatment can prevent calcification progression and improve prognosis.
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