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The effect of melatonin supplementation on glycemic control in patients with type 2 diabetes
Xutong Lv1, Huiqi Sun1, Shuang Ai2
1Master Degree Candidate, First School of Clinical Medicine, Shandong University of Traditional Chinese Medicine, Jinan, China.
Background And Purpose:
Melatonin supplementation has shown potential benefits in the management of diabetes in clinical trials; however, prior meta-analyses have not specifically focused on individuals with type 2 diabetes mellitus (T2DM). This study investigates the efficacy of melatonin supplementation in improving glycemic control among patients with T2DM by systematically reviewing and analyzing data from randomized controlled trials (RCTs).
Methods:
A comprehensive literature search was conducted in PubMed, Cochrane Library, Scopus, Web of Science, and Embase from their inception to September 2024. RCTs evaluating the effects of melatonin supplementation in adults diagnosed with T2DM were included. The methodological quality of the studies was assessed using the Cochrane Risk of Bias Tool. Data were synthesized and analyzed using RevMan version 5.3.
Results:
A total of nine RCTs were included in the meta-analysis (n=9). These studies collectively involved 427 participants. Melatonin supplementation was associated with a statistically significant reduction in glycated hemoglobin (HbA1c) levels compared to placebo [mean difference [MD]: -0.65; 95% CI: -1.28, -0.02; P = 0.04], However, no significant effect was observed on fasting plasma glucose (FPG) levels [mean difference: -6.40; 95% CI: -15.79, 2.99; P = 0.18].
Conclusion:
This meta-analysis suggests that melatonin supplementation significantly reduces HbA1c levels in patients with type 2 diabetes mellitus compared to placebo, indicating potential benefits for long-term glycemic control. However, no significant effect was observed on FPG levels.
Systematic Review Registration:
https://www.crd.york.ac.uk/PROSPERO/, identifier CRD42024629557.
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