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A Multidisciplinary Aortopathy Clinic: The McGill Experience
Masaki Kodaira1,2,3, Kevin Lachapelle4, Richard L Leask5
1Division of Cardiology, McGill University, Montreal, Quebec, Canada.
Insights
Multidisciplinary aortopathy clinics provide comprehensive care for thoracic aortic disease (TAD) patients. This 8-year study shows this approach ensures precise and timely management for complex cases.
Area of Science:
- Cardiovascular Medicine
- Genetics
- Radiology
Background:
- Thoracic aortic disease (TAD) patients require specialized care due to their complex and high-risk nature.
- Multidisciplinary aortopathy clinics are recommended but underreported.
- This study details the experience of an 8-year-old multidisciplinary aortopathy clinic.
Purpose of the Study:
- To evaluate the effectiveness of a multidisciplinary approach in managing thoracic aortic disease.
- To assess the impact of specialized imaging reanalysis and genetic testing in TAD patient care.
- To demonstrate the comprehensive, precise, and timely care provided by such a clinic.
Main Methods:
- Evaluated 567 patients with TAD from September 2016 to May 2024.
- Utilized a multidisciplinary team including cardiac/vascular surgeons, cardiologist, radiologist, geneticists, and researchers.
- Performed external imaging reanalysis and genetic testing for hereditary TADs.
Main Results:
- Radiologist reanalysis of external imaging altered clinical decisions in 9.8% of cases.
- Genetic testing identified a positive TAD gene in 12.8% of tested patients.
- 7% of patients underwent surgery within a median of 2.7 months.
Conclusions:
- An 8-year experience at McGill University's aortopathy clinic confirms the value of a multidisciplinary approach.
- This model delivers complete, precise, and timely care for complex thoracic aortic disease patients.
- The study highlights the successful integration of surgical, medical, radiological, and genetic expertise.
Background:
Guidelines recommend that patients with thoracic aortic disease (TAD) be seen in a multidisciplinary aortopathy clinic, because of their complex and high-risk profile. However, reports on such clinics are limited.
Methods:
From September 2016 to May 2024, we evaluated 567 patients with TAD. They were seen by our multidisciplinary team, which is comprised of 1 cardiac surgeon, 2 vascular surgeons, 1 cardiologist, 1 cardiothoracic radiologist, a team of 4 engineering researchers, a dedicated member from the genetics department, and an administrative assistant. For patients who had computed tomography or magnetic resonance imaging performed outside our institution, image reanalysis was conducted by our cardiothoracic radiologist. Genetic testing was performed for patients with suspected hereditary TADs.
Results:
Reanalysis of external computed tomography and/or magnetic resonance imaging by our radiologist altered clinical decision-making in 5 of 51 cases (9.8%). Genetic testing that examined 25 genes associated with Marfan syndrome and related aortopathies was conducted on 250 patients, revealing a positive TAD gene in 32 (12.8%), a variant of unknown significance in 99 (39.6%), and a negative result in 119 (47.6%). Forty patients (7%) had surgery within a median of 2.7 months (quartile 1-quartile 3: 1.1-4.9) from their initial clinic visit.
Conclusions:
Our 8-year experience at the aortopathy clinic of McGill University demonstrates that a multidisciplinary approach to TAD can deliver complete, precise, and timely care to this complex patient population.
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