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Published on: February 4, 2017
Evaluating a triaza-18-crown-6 picolinate chelator for [212/203Pb]Pb2+ and [212/213Bi]Bi3+ theranostics
Desiree Fiaccabrino1,2, Tinotenda Masvikeni1, Brooke L McNeil2,3
1Medicinal Inorganic Chemistry Group, Department of Chemistry, University of British Columbia, 2036 Main Mall, Vancouver, British Columbia V6T 1Z1, Canada. orvig@chem.ubc.ca.
Abstract:
H3tripa (H3macrotripa), a triaza-18-crown-6 macrocycle bearing three picolinate arms, enables quantitative radiolabeling of [203Pb]Pb2+ and [213Bi]Bi3+ and exhibits robust human serum stability. NMR spectroscopy, X-ray crystallography, density functional theory, and UV-potentiometry investigate its coordination geometry and thermodynamics with Bi3+ and Pb2+, highlighting H3tripa as a promising Pb/Bi theranostic chelator.
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