WITHDRAWN: LINC-PINT: A Distinctive Long Non-Coding RNA Functioning as a Potential Suppressor in Tumorigenesis

Area of Science:

• Molecular Biology
• Oncology
• Genetics

Background:

• Long noncoding RNAs (lncRNAs) are crucial regulators of biological processes and implicated in various diseases, including cancer.
• Initially considered transcriptional byproducts, lncRNAs are now known to influence chromatin structure, transcription, RNA processing, translation, and nuclear transport.
• LINC-PINT, a P53-induced lncRNA, demonstrates significant tumor suppressor activity across diverse cancer types.

Purpose of the Study:

• To provide a comprehensive overview of the functions and mechanisms of LINC-PINT in cancer.
• To analyze existing literature on LINC-PINT's role in tumor suppression.

Main Methods:

• A systematic literature review was conducted using the PubMed database.
• Inclusion criteria focused on relevance, study quality, and data availability.
• Analysis encompassed 128 studies detailing LINC-PINT's functions and mechanisms in various cancers.

Main Results:

• LINC-PINT functions as a tumor suppressor in numerous cancers, including breast, lung, gastric, and liver cancers.
• Its mechanisms involve promoting apoptosis and senescence, inhibiting proliferation, migration, invasion, and drug resistance.
• LINC-PINT also impacts cell stemness, epithelial-mesenchymal transition (EMT), radioresistance, and DNA damage repair.

Conclusions:

• LINC-PINT acts as a tumor suppressor through mechanisms like miRNA sponging, epigenetic regulation, and DNA damage repair modulation.
• Its complex and tissue-specific functions require further investigation.
• LINC-PINT holds potential as a therapeutic target for cancer treatment, necessitating continued clinical validation.