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Association Between Inflammatory Markers and Cognitive Function in Adults With Bipolar Disorder: A Systematic Review.
David R A Coelho1,2,3, Jennifer Nicoloro Santabarbara2,4, Marzieh Majd2,4
1Division of Neuropsychiatry and Neuromodulation, Massachusetts General Hospital, Boston, Massachusetts, USA.
Acta Psychiatrica Scandinavica
|July 23, 2025
Summary
Inflammation is linked to cognitive issues in bipolar disorder (BD). Key markers like CRP, TNF-α, IL-6, and IL-1RA correlate with impaired executive function, processing speed, and memory in BD patients.
Area of Science:
- Neuroscience
- Psychiatry
- Immunology
Background:
- Bipolar disorder (BD) frequently involves cognitive dysfunction, impacting patient recovery and quality of life.
- Inflammation is increasingly recognized as a potential contributor to cognitive deficits in BD.
Conclusions:
- A consistent association exists between inflammation and cognitive dysfunction in BD, particularly involving specific markers and cognitive domains.
- Targeting inflammation may be a promising strategy for improving cognitive health in BD.
- Future research should focus on longitudinal designs and central inflammatory markers.
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