Endometrial diseases: a summary of small experimental animal model†

Endometrium plays a crucial role in embryonic growth and development. Endometrial-related diseases, such as endometritis, endometriosis, endometrial cancer, and intrauterine adhesions, hurt fertility and women's health. At present, these diseases often lack effective or permanent treatments, necessitating the construction of analogous animal models for research and solution development. To mitigate the waste of time, financial resources, and the potential for excessive harm to animals resulting from the utilization of unsuitable animal models, it is imperative to judiciously select the appropriate models. Given that most laboratories have limited space and equipment, as well as employ a high percentage of small rodents, this review aims to provide a comprehensive summary of the small experimental animals currently used in the establishment of models for endometrial-related diseases, especially for their operational methodologies, applications, challenges associated with the techniques, and prospects for future development.